--- title: Buy Generic Uniphyl Cr Theophylline 400mg Pills description: Uniphyl Cr (Theophylline) is a bronchodilator for asthma and COPD. Order these 400mg controlled-release pills from our trusted online pharmacy. type: product language: en url: https://liabilis.com/order-uniphyl_cr-online-en.html availability: in_stock shipping: - type: Standard Airmail price: 10.00 currency: USD area: Worldwide time: 14-21 days - type: Tracked Express price: 30.00 currency: USD area: Worldwide tracking: true time: 5-9 days price_min: 38.99 price_max: 243.19 currency: USD offers: - name: 400mg x 30 pills price: 38.99 - name: 400mg x 60 pills price: 56.76 - name: 400mg x 90 pills price: 74.25 - name: 400mg x 120 pills price: 101.99 - name: 400mg x 180 pills price: 138.99 - name: 400mg x 360 pills price: 243.19 --- # Buy Generic Uniphyl Cr Theophylline 400mg Pills Uniphyl Cr contains the active ingredient Theophylline, a methylxanthine bronchodilator used for the treatment of asthma, chronic bronchitis, and other lung diseases. This controlled-release formulation provides 24-hour coverage for respiratory conditions. The medication is designed for adults managing chronic obstructive pulmonary disease or asthma. Our pharmacy offers Uniphyl Cr in reliable 400mg controlled-release pills. ## Pricing and Options | Dosage | Pack Size | Price (USD) | Price Per Pill | Status | | :--- | :--- | :--- | :--- | :--- | | **400mg** | 30 pills | **$38.99** | $1.31 | In Stock | | **400mg** | 60 pills | **$56.76** | $0.95 | In Stock | | **400mg** | 90 pills | **$74.25** | $0.83 | In Stock | | **400mg** | 120 pills | **$101.99** | $0.85 | In Stock | | **400mg** | 180 pills | **$138.99** | $0.77 | In Stock | | **400mg** | 360 pills | **$243.19** | $0.67 | In Stock | [Buy Now](https://liabilis.com/order-uniphyl_cr-online-en.html) ## Introduction Uniphyl Cr is a generic oral medication that contains the active compound theophylline. It is supplied as a 400 mg tablet and belongs to the class of methyl-xanthine bronchodilators. Theophylline works by relaxing airway smooth muscle and reducing the inflammatory response in the lungs, making Uniphyl Cr useful for managing chronic obstructive pulmonary disease (COPD) and asthma when other therapies are insufficient. Secondary applications such as adjunct treatment for apnea of prematurity are recognized in some clinical settings, although they remain off-label. --- ## Quick Reference Facts ``` **Active Ingredient** : Theophylline **Form** : pill 400 mg **Primary Uses** : • Chronic obstructive pulmonary disease (COPD) • Asthma (as add-on therapy) ``` --- ## What is Uniphyl Cr? Uniphyl Cr is the generic version of medications containing the active compound theophylline. It is marketed in tablet form with a fixed strength of 400 mg per pill. Theophylline-containing products have been available for decades and are listed in many national pharmacopeias. Uniphyl Cr is produced by an international manufacturer that complies with Good Manufacturing Practices, although the specific company name is not disclosed in publicly available registries. As a generic, Uniphyl Cr offers the same therapeutic effects as brand-name theophylline products such as Theo-Dur and Theophylline Sandoz, while typically costing less. --- ## How Uniphyl Cr Works Theophylline belongs to the methyl-xanthine family and exerts its bronchodilator effect through several mechanisms: - **Phosphodiesterase inhibition:** By blocking phosphodiesterase-4, theophylline raises intracellular cyclic AMP, leading to relaxation of bronchial smooth muscle. - **Adenosine receptor antagonism:** The drug blocks adenosine receptors in the airway, reducing bronchoconstriction triggered by endogenous adenosine. - **Anti-inflammatory actions:** Theophylline modestly suppresses inflammatory cell activity, contributing to improved airway patency over time. After oral ingestion, the tablet is absorbed mainly in the small intestine. Peak plasma concentrations occur within 1-2 hours, and the drug has a half-life of 6-8 hours in healthy adults, although this can be prolonged in the presence of liver disease or certain drug interactions. Metabolism occurs primarily via the cytochrome P450 1A2 isoenzyme, and renal excretion eliminates the inactive metabolites. --- ## Conditions Treated with Uniphyl Cr - **Chronic Obstructive Pulmonary Disease (COPD)** Theophylline improves airflow by dilating bronchi, which can reduce the frequency of exacerbations in patients who remain symptomatic despite inhaled bronchodilators. - **Asthma (add-on therapy)** For adults whose asthma is not fully controlled with inhaled corticosteroids and long-acting β-agonists, theophylline can provide additional bronchodilation and allow better symptom control. - **Bronchial Hyper-responsiveness** The drug’s anti-inflammatory properties help diminish airway hyper-reactivity, contributing to fewer asthma attacks. *Note: Only the above indications are approved by major regulatory agencies for theophylline-containing products.* --- ## Is Uniphyl Cr the Right Medication for You? Uniphyl Cr is appropriate for adult patients who: - Have a confirmed diagnosis of COPD or asthma that remains inadequately controlled with standard inhaled therapies. - Require an oral bronchodilator because inhaler technique is suboptimal or adherence to inhaled medication is problematic. Clinical scenarios favoring Uniphyl Cr include frequent nocturnal symptoms, limited response to inhaled β-agonists, or a need for a long-acting oral agent during hospital discharge. **Contraindications and cautions** include: - Known hypersensitivity to theophylline or any methyl-xanthine. - Uncontrolled cardiac arrhythmias, severe coronary artery disease, or recent myocardial infarction. - Active seizure disorder. - Significant hepatic impairment, which can markedly increase serum theophylline levels. Patients with these conditions should avoid Uniphyl Cr or use it only under strict medical supervision. Dose adjustments are also required in the elderly, smokers, and those taking interacting medications. --- ## Buying Uniphyl Cr from [our online pharmacy](https://liabilis.com/order-uniphyl_cr-online-en.html) ### Why Choose Our Service? Accessing theophylline can be challenging due to limited stock in some regions and higher prices for brand-name versions. [our online pharmacy](https://liabilis.com/order-uniphyl_cr-online-en.html) provides a reliable, cost-effective pathway to obtain Uniphyl Cr, helping patients maintain their prescribed therapy without unnecessary expense. ### Quality & Safety Assurance We partner with licensed international pharmacies to ensure quality and authenticity. Every shipment is verified against the manufacturer’s batch records and complies with recognized regulatory standards. ### Pricing & Access Uniphyl Cr is offered at a price close to the wholesale cost, delivering savings of up to 40 % compared with brand equivalents such as Theo-Dur. This makes long-term therapy more affordable for patients who need daily dosing. ### Discreet Delivery Orders are packaged in unmarked, tamper-evident envelopes and dispatched via express courier with delivery typically within 7 days, or standard airmail in approximately 3 weeks. Your privacy is protected throughout the process. --- ## Use: Dosing, Missed Dose, Overdose **Standard dosing (adults)** - One 400 mg tablet taken two to three times daily, adjusted to maintain therapeutic serum concentrations (generally 10-20 µg/mL). Exact dosing must be individualized by a healthcare professional. **Missed dose** - If a scheduled dose is forgotten and the next dose is more than 4 hours away, take the missed tablet. If the next dose is imminent, skip the missed tablet and continue with the regular schedule. Do not double-dose. **Overdose** - Symptoms may include nausea, vomiting, rapid heartbeat, seizures, or severe tremor. Seek emergency medical attention immediately. If possible, provide the amount ingested and the time of ingestion to the care team. **Practical precautions** - Take tablets with a full glass of water; they may be taken with or without food. - Avoid excessive caffeine or other methyl-xanthine-containing products, as they can increase toxicity risk. - Refrain from operating heavy machinery or driving until you know how Uniphyl Cr affects you, especially during the first few days of therapy. - Alcohol can potentiate central nervous system side effects; limit intake. --- ## Safety Information ### ⚠️ Who Should Not Take Uniphyl Cr - Patients with a documented hypersensitivity to theophylline or related compounds. - Individuals with uncontrolled cardiac arrhythmias, recent myocardial infarction, or severe coronary artery disease. - Persons with a history of seizures or active epilepsy. - Those with marked hepatic dysfunction (e.g., cirrhosis) or severe renal impairment without dose adjustment. ### Common Side Effects - **Nausea / upset stomach** - mild and often transient. - **Headache** - usually resolves with continued use or dose adjustment. - **Insomnia** - take the evening dose earlier in the day if sleep is disturbed. - **Tremor** - generally dose-related; lower the dose if persistent. These effects are typically mild and manageable; patients should report any that interfere with daily activities. ### Serious Side Effects (Seek Immediate Medical Help) - **Cardiac arrhythmias** (palpitations, irregular heartbeat). - **Seizures** - any convulsive episode requires urgent evaluation. - **Severe allergic reactions** (rash, swelling, difficulty breathing). If any of these occur, contact emergency services promptly. ### Drug & Food Interactions - **CYP1A2 inhibitors** (e.g., ciprofloxacin, erythromycin, fluvoxamine) → increase theophylline levels, risk of toxicity. - **CYP1A2 inducers** (e.g., smoking, rifampin, carbamazepine) → lower serum concentrations, may reduce efficacy. - **Cimetidine** → reduces hepatic clearance, may raise theophylline levels. - **Macrolide antibiotics** (e.g., clarithromycin) → potentiate theophylline toxicity. - **Alcohol** → can enhance central nervous system side effects. Patients should disclose all current medications, including over-the-counter products and supplements, to their prescriber. --- ## Off-Label and Investigational Uses of Uniphyl Cr - **Apnea of prematurity** - Clinical studies have shown theophylline can stimulate respiratory drive in preterm infants, reducing apnea episodes. Use is limited to neonatal intensive-care settings and must be supervised by a neonatologist. - **Chronic cough** - Some trials suggest theophylline may suppress cough reflex sensitivity, though evidence is modest. - **Pulmonary hypertension** - Small studies indicate potential vasodilatory benefits, but theophylline is not approved for this indication. These applications have not received formal regulatory approval for Uniphyl Cr. Any off-label use should only be undertaken under direct supervision of a qualified healthcare provider. --- ## Storage & Handling - Store tablets at **20-25 °C (68-77 °F)** in a dry place, protected from moisture and direct sunlight. - Keep the container tightly closed to maintain tablet integrity. - Do not use if the product shows signs of physical deterioration (crumbling, discoloration). - Dispose of unused tablets according to local hazardous-waste regulations or return them to a pharmacy for safe disposal. --- ## Frequently Asked Questions **Practical Use & Lifestyle** - **Can I travel internationally with Uniphyl Cr?** Yes, but keep the medication in its original labeled container, carry a copy of your prescription, and be aware of import regulations in your destination country. - **Does caffeine affect Uniphyl Cr therapy?** Caffeine is a methyl-xanthine and can add to theophylline’s stimulant effects, potentially increasing side-effect risk. Moderate consumption is advisable. - **Is it safe to take Uniphyl Cr while exercising?** Most patients tolerate normal physical activity, but vigorous exercise may exacerbate tremor or palpitations. Monitor your response and discuss any concerns with your provider. **Product & Formulation Details** - **What does a Uniphyl Cr tablet look like?** The tablet is round, white to off-white, imprinted with “UC-400”. Appearance may vary slightly between batches. - **Are there any inactive ingredients I should be aware of?** Inactive components typically include lactose, microcrystalline cellulose, and magnesium stearate. Patients with lactose intolerance should verify with the supplier. **Regulatory & Safety Nuances** - **Will Uniphyl Cr appear on a drug test for athletes?** Theophylline is not a prohibited substance by most sporting agencies, but athletes should check the specific regulations of their governing body. - **Is Uniphyl Cr safe for pregnant women?** Theophylline crosses the placenta and is classified as Pregnancy Category C. Use only if the potential benefit justifies the potential risk, and under close medical supervision. - **Can the elderly use Uniphyl Cr safely?** Older adults often have reduced clearance, increasing the risk of toxicity. Dose reductions and serum level monitoring are commonly recommended. **Scientific & Clinical Curiosity** - **How does Uniphyl Cr compare to inhaled bronchodilators?** Inhaled agents provide rapid, targeted airway relaxation, whereas Uniphyl Cr offers a systemic effect with a longer duration but slower onset. Both can be complementary in severe disease. - **What major clinical trials have evaluated theophylline?** Large randomized studies in the 197s-199s, such as the "Theophylline versus Placebo in COPD" trial, demonstrated modest improvements in lung function and symptom scores. - **Why does smoking alter Uniphyl Cr effectiveness?** Polycyclic aromatic hydrocarbons in cigarette smoke induce CYP1A2, accelerating theophylline metabolism and lowering plasma concentrations, often requiring higher doses. --- ## Glossary **Theophylline** : A methyl-xanthine bronchodilator that relaxes airway smooth muscle and exerts modest anti-inflammatory effects. **Bronchodilator** : A medication that widens the air passages of the lungs, improving airflow and oxygen exchange. **CYP1A2** : An enzyme in the liver responsible for metabolizing many drugs, including theophylline; its activity can be increased or decreased by other substances. **Therapeutic Index** : The ratio between a drug’s toxic dose and its effective dose; a narrow index, as with theophylline, requires careful monitoring. **Bioavailability** : The proportion of an administered dose that reaches systemic circulation in an active form. --- ## Disclaimer The information provided about **Uniphyl Cr** is for general knowledge only. It does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. [our online pharmacy](https://liabilis.com/order-uniphyl_cr-online-en.html) offers access to **Uniphyl Cr** for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.