--- title: Buy Generic Sprycel Dasatinib 50mg Bottle Online description: Generic Sprycel containing Dasatinib 50mg treats certain types of leukemia. Order trusted cancer medication from our secure online pharmacy. type: product language: en url: https://liabilis.com/order-sprycel-online-en.html availability: in_stock shipping: - type: Standard Airmail price: 10.00 currency: USD area: Worldwide time: 14-21 days - type: Tracked Express price: 30.00 currency: USD area: Worldwide tracking: true time: 5-9 days price_min: 189.99 price_max: 509.99 currency: USD offers: - name: 50mg x 1 bottle price: 189.99 - name: 50mg x 2 bottles price: 345.79 - name: 50mg x 3 bottles price: 509.99 --- # Buy Generic Sprycel Dasatinib 50mg Bottle Online Sprycel is a generic medication containing Dasatinib, originally developed by Bristol-Myers Squibb. It is used to treat certain types of leukemia including chronic myeloid leukemia and acute lymphoblastic leukemia. This tyrosine kinase inhibitor works by blocking abnormal proteins that promote cancer cell growth. It is prescribed for adults with specific blood cancer conditions requiring targeted therapy. Our pharmacy offers reliable access to Sprycel containing Dasatinib in 50mg bottle form for effective leukemia treatment. ## Pricing and Options | Dosage | Pack Size | Price (USD) | Price Per Pill | Status | | :--- | :--- | :--- | :--- | :--- | | **50mg** | 1 bottle | **$189.99** | $189.99 | In Stock | | **50mg** | 2 bottles | **$345.79** | $172.90 | In Stock | | **50mg** | 3 bottles | **$509.99** | $170.00 | In Stock | [Buy Now](https://liabilis.com/order-sprycel-online-en.html) ## Introduction Sprycel is a medication that contains the active ingredient dasatinib. It is supplied as a 50 mg tablet packaged in a bottle and belongs to the class of tyrosine-kinase inhibitors (TKIs). Dasatinib is approved for the treatment of certain leukemias, specifically chronic-phase chronic myeloid leukemia (CML) and Philadelphia-positive acute lymphoblastic leukemia (Ph⁺ ALL). The drug works by blocking abnormal enzymes that drive the growth of cancer cells, thereby helping to restore normal blood cell production. --- ## Quick Reference Facts ``` **Active Ingredient** : Dasatinib **Form** : tablet 50 mg (bottle) **Primary Uses** : • Chronic-phase chronic myeloid leukemia (CML) • Philadelphia-positive acute lymphoblastic leukemia (Ph⁺ ALL) ``` --- ## What is Sprycel? Sprycel is the generic version of medications containing the active compound dasatinib. Dasatinib is marketed under brand names such as Sprycel and Ba­c-Da-T. The generic formulation offers the same molecular composition, strength, and therapeutic effect as the branded product, meeting strict bioequivalence standards set by regulatory agencies. Dasatinib was originally developed by Bristol-Myers Squibb and received FDA approval in 2006 for the treatment of CML. As a generic, Sprycel provides a cost-effective alternative while maintaining the same safety and efficacy profile as the brand-named drug. --- ## How Sprycel Works Dasatinib is a second-generation BCR-ABL tyrosine-kinase inhibitor. In CML and Ph⁺ ALL, the BCR-ABL fusion protein is constitutively active, continuously signaling cells to proliferate. Dasatinib binds to the ATP-binding site of BCR-ABL as well as several Src family kinases, preventing phosphorylation of downstream substrates. This blockade halts the uncontrolled growth of leukemic cells and can induce apoptosis. Pharmacokinetically, dasatinib is rapidly absorbed after oral ingestion, achieving peak plasma concentrations within .5-3 hours. Food can increase its bioavailability modestly, so it is usually taken with a light meal. The drug is extensively metabolized by CYP3A4 and eliminated primarily via feces; the average terminal half-life is about 3-5 hours, allowing once-daily dosing. --- ## Conditions Treated with Sprycel - **Chronic-phase chronic myeloid leukemia (CML)** - Dasatinib inhibits the BCR-ABL kinase that drives the disease, leading to hematologic and cytogenetic responses in the majority of patients. - **Philadelphia-positive acute lymphoblastic leukemia (Ph⁺ ALL)** - By targeting the same oncogenic kinase, dasatinib helps achieve remission when combined with conventional chemotherapy. These indications are approved by the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA). --- ## Is Sprycel the Right Medication for You? Sprycel is appropriate for adult patients with newly diagnosed chronic-phase CML who have no contraindicating conditions, as well as for those with Ph⁺ ALL undergoing multi-agent therapy. It is also considered for patients who have experienced intolerance or suboptimal response to first-generation TKIs such as imatinib. Contraindications include known hypersensitivity to dasatinib or any of the tablet’s excipients. Caution is advised in patients with severe hepatic impairment, uncontrolled cardiovascular disease, or a history of pleural effusion, as dasatinib can exacerbate these conditions. The decision to use Sprycel should be made by a hematologist familiar with the patient’s disease stage, comorbidities, and prior treatment history. --- ## Buying Sprycel from [our online pharmacy](https://liabilis.com/order-sprycel-online-en.html) ### Why Choose Our Service? Accessing specialty oncology medicines can be challenging due to insurance restrictions or limited pharmacy stock. Our platform offers a straightforward way to obtain Sprycel at a price that is close to the manufacturer’s cost, helping to reduce out-of-pocket expenses. ### Quality & Safety Assurance We partner with licensed international pharmacies to ensure quality and authenticity. Every batch of Sprycel is sourced from manufacturers that comply with Good Manufacturing Practice (GMP) standards and is inspected by third-party laboratories before shipment. ### Pricing & Access Because Sprycel is available as a generic, the cost is substantially lower than the branded version. [our online pharmacy](https://liabilis.com/order-sprycel-online-en.html) makes it possible for patients to receive the 50 mg tablets without the premium pricing often seen in conventional retail settings. ### Discreet Delivery Orders are packed in unbranded, tamper-evident packaging and shipped via express courier, typically arriving within 7 days. Standard airmail delivery is available for remote locations and usually arrives in approximately 3 weeks. All personal information is handled with strict confidentiality. --- ## Use: Dosing, Missed Dose, Overdose - **Standard dosing** (based on FDA labeling): - Chronic-phase CML: 100 mg once daily (dose may be reduced to 50 mg for patients who experience significant fluid retention or cytopenias). - Ph⁺ ALL: 140 mg once daily (dose may be reduced to 100 mg or 50 mg depending on tolerability). - **Missed dose:** - If a dose is missed and it is less than 8 hours before the next scheduled dose, skip the missed tablet and resume the regular schedule. Do not double the dose. - **Overdose:** - In the event of an overdose, seek emergency medical attention immediately. Supportive care, including hydration and monitoring of cardiac and pulmonary status, is the mainstay of treatment. - **Practical precautions:** - Take Sprycel with a light meal to improve absorption. - Avoid grapefruit juice, as it can increase plasma concentrations. - Refrain from operating heavy machinery until you know how the medication affects you, especially during the first weeks of therapy. --- ## Safety Information ### ⚠️ Who Should Not Take Sprycel - Patients with documented hypersensitivity to dasatinib or any tablet ingredient. - Individuals with severe hepatic impairment (Child-Pugh class C) due to lack of sufficient safety data. - Patients with uncontrolled cardiovascular disease who have experienced recent myocardial infarction or severe arrhythmias. ### Common Side Effects - **Fluid retention / pleural effusion** (occurs in up to 20 % of patients): monitor for shortness of breath and report promptly. - **Myelosuppression** (neutropenia, thrombocytopenia, anemia): complete blood counts are checked regularly. - **Gastrointestinal upset** (nausea, diarrhea, abdominal pain): usually mild and manageable with diet adjustments. ### Serious Side Effects (Seek Immediate Medical Help) - **Pulmonary arterial hypertension** - sudden dyspnea or fatigue warrants urgent evaluation. - **Severe hemorrhage** - any unexpected bleeding, especially gastrointestinal or intracranial, requires emergency care. - **Severe rash or Stevens-Johnson syndrome** - discontinue Sprycel and seek immediate attention. ### Drug & Food Interactions - **Strong CYP3A4 inhibitors** (e.g., ketoconazole, clarithromycin): can raise dasatinib levels, increasing toxicity risk - dose reduction may be needed. - **CYP3A4 inducers** (e.g., rifampin, carbamazepine): may lower dasatinib concentrations, potentially reducing efficacy. - **Proton-pump inhibitors** (omeprazole, esomeprazole): reduce absorption; separate administration by at least 2 hours. - **Anticoagulants** (warfarin, direct oral anticoagulants): heightened bleeding risk; monitor coagulation parameters closely. --- ## Off-Label and Investigational Uses of Sprycel - **Chronic myeloid leukemia in accelerated or blast phase** - Small case series suggest dasatinib can induce cytogenetic responses, but robust data are lacking and regulatory approval is limited to chronic phase. - **Systemic mastocytosis** - Dasatinib has shown activity against KIT D816V mutations in early-phase trials; however, it remains investigational. - **Solid tumor trials** - Certain studies evaluate dasatinib as a Src-family kinase inhibitor in breast and prostate cancer, but no definitive efficacy has been established. All off-label use should occur only under the direct supervision of a qualified hematologist or oncologist, with informed consent and close monitoring. --- ## Storage & Handling - **Temperature:** Store at 20-25 °C (68-77 °F); excursions between 15-30 °C are acceptable. - **Light/Humidity:** Keep tablets in the original bottle, tightly closed, and protect from excess moisture and direct sunlight. - **Expiry:** Do not use after the printed expiration date. - **Disposal:** Unused tablets should be returned to a pharmacy take-back program or disposed of according to local regulations to avoid environmental contamination. --- ## Frequently Asked Questions **Practical Use & Lifestyle** - **Can I travel internationally with Sprycel?** Yes. Carry the medication in its original labeling and a copy of the prescription (if required). Keep it in your carry-on luggage to avoid temperature extremes in checked baggage. - **Does alcohol affect Sprycel?** Moderate alcohol intake does not directly interact with dasatinib, but excessive drinking can worsen liver function and increase the risk of cytopenias. Limit alcohol and discuss consumption levels with your clinician. - **Will taking Sprycel with a high-fat meal change its effect?** A high-fat meal can modestly increase dasatinib exposure. To maintain consistent absorption, take the tablet with a light meal rather than a large, fatty one. **Product & Formulation Details** - **What do Sprycel tablets look like?** Sprycel tablets are round, film-coated, white, and bear the imprint “50 mg”. Generic tablets may vary slightly in size or imprint depending on the manufacturer. - **Are there any inactive ingredients I should be aware of?** Common excipients include lactose, magnesium stearate, and microcrystalline cellulose. Patients with severe lactose intolerance should verify the specific formulation with the pharmacy. - **Can the tablets be split?** Dasatinib tablets are not scored, and splitting may result in uneven dosing. If a lower dose is required, clinicians usually prescribe a different strength rather than recommend splitting. **Regulatory & Safety Nuances** - **Is Sprycel safe for pregnant or nursing mothers?** Dasatinib is classified as pregnancy category D (positive evidence of risk). It is contraindicated during pregnancy and breastfeeding because it can cause fetal harm and is excreted in breast milk. - **Will Sprycel show up on a standard drug test?** Routine employment drug screens do not detect dasatinib, as it is not a substance of abuse. However, specialized tests could identify its presence if specifically requested. - **Are there age-related dosing adjustments?** Sprycel is approved for adult patients only. Pediatric dosing requires enrollment in clinical trials and is not covered by standard labeling. **Scientific & Clinical Curiosity** - **What was the key trial that led to Sprycel’s approval?** The DASISION trial (Dasatinib versus Imatinib Study in Treatment-Naïve CML Patients) demonstrated higher rates of complete cytogenetic response with dasatinib, forming the primary basis for FDA approval in chronic-phase CML. - **How does dasatinib differ from imatinib?** Dasatinib binds to both active and inactive conformations of the BCR-ABL kinase and also inhibits several Src family kinases, providing broader activity against resistant BCR-ABL mutations. Imatinib primarily targets the inactive conformation and has a narrower kinase inhibition profile. --- ## Glossary **Tyrosine-Kinase Inhibitor (TKI)** : A class of drugs that block enzymes (tyrosine kinases) involved in signaling pathways that promote cancer cell growth. **Pleural Effusion** : Accumulation of fluid in the space surrounding the lungs, a known adverse effect of dasatinib that can cause shortness of breath. **CYP3A4** : An enzyme in the liver that metabolizes many medications; inhibitors increase drug levels, while inducers reduce them. **Cytogenetic Response** : A reduction or disappearance of the abnormal chromosome (Philadelphia chromosome) in bone-marrow cells, indicating treatment effectiveness in CML. --- ## Disclaimer The information provided about **Sprycel** is intended for general educational purposes only and does not substitute professional medical consultation. All therapeutic decisions, including those concerning off-label applications, should be made under the guidance of a qualified healthcare professional. Readers are presumed to be competent adults capable of making informed health choices. [our online pharmacy](https://liabilis.com/order-sprycel-online-en.html) makes Sprycel accessible for individuals who may encounter limited availability through traditional channels or who seek cost-effective generic alternatives. Always discuss with your physician before initiating, modifying, or discontinuing any medication.