--- title: Buy Generic Roflumilast 500mg Pills Online description: Roflumilast 500mg Pills treat severe COPD by reducing inflammation. Order this trusted medication from our secure online pharmacy. type: product language: en url: https://liabilis.com/order-roflumilast-online-en.html availability: in_stock shipping: - type: Standard Airmail price: 10.00 currency: USD area: Worldwide time: 14-21 days - type: Tracked Express price: 30.00 currency: USD area: Worldwide tracking: true time: 5-9 days price_min: 65.54 price_max: 208.99 currency: USD offers: - name: 500mg x 30 pills price: 65.54 - name: 500mg x 60 pills price: 104.49 - name: 500mg x 90 pills price: 141.99 - name: 500mg x 120 pills price: 157.69 - name: 500mg x 180 pills price: 208.99 --- # Buy Generic Roflumilast 500mg Pills Online Roflumilast is a phosphodiesterase-4 inhibitor that reduces inflammation in the lungs to prevent COPD exacerbations. It is used for severe chronic obstructive pulmonary disease with chronic bronchitis to improve lung function and reduce flare-ups. This medication is designed for adults with severe COPD seeking to reduce exacerbation frequency. Our pharmacy offers roflumilast in 500mg tablet form for daily maintenance therapy. ## Pricing and Options | Dosage | Pack Size | Price (USD) | Price Per Pill | Status | | :--- | :--- | :--- | :--- | :--- | | **500mg** | 30 pills | **$65.54** | $2.18 | In Stock | | **500mg** | 60 pills | **$104.49** | $1.74 | In Stock | | **500mg** | 90 pills | **$141.99** | $1.58 | In Stock | | **500mg** | 120 pills | **$157.69** | $1.31 | In Stock | | **500mg** | 180 pills | **$208.99** | $1.16 | In Stock | [Buy Now](https://liabilis.com/order-roflumilast-online-en.html) ## Introduction Roflumilast is an oral medication used to reduce the risk of COPD (chronic obstructive pulmonary disease) exacerbations in patients with severe disease accompanied by chronic bronchitis. The active ingredient is roflumilast, supplied as a pill. In the information provided the listed tablet strength is 500 mg; regulatory authorities, however, approve a 500 µg (.5 mg) dose taken once daily. Roflumilast belongs to the class of phosphodiesterase-4 (PDE4) inhibitors, a therapeutic group that modulates inflammatory pathways in the lungs. Its primary indication is maintenance therapy for COPD, with secondary investigation into other inflammatory conditions. --- ## Quick Reference Facts **Active Ingredient** : roflumilast **Form** : pill 500 mg **Primary Uses** : - Prevention of COPD exacerbations in severe disease with chronic bronchitis --- ## What is Roflumilast? Roflumilast is the generic version of medications containing the active compound roflumilast. It is marketed worldwide as an oral tablet formulation. The branded product Daliresp®, produced by Takeda Pharmaceutical, was the first FDA-approved PDE4 inhibitor for COPD. Generic roflumilast offers the same pharmacologic profile as its branded counterpart, meeting bioequivalence standards set by health authorities. The drug is intended for adult patients with severe COPD who continue to experience frequent flare-ups despite optimal bronchodilator therapy. --- ## How Roflumilast Works Roflumilast selectively inhibits the enzyme phosphodiesterase-4, which degrades cyclic adenosine monophosphate (cAMP) inside inflammatory cells. By blocking PDE4, intracellular cAMP concentrations rise, leading to reduced release of pro-inflammatory mediators such as tumor necrosis factor-α, interleukin-8, and leukotrienes. This dampened inflammatory cascade lessens airway edema and mucus hypersecretion, thereby decreasing the frequency and severity of COPD exacerbations. The tablet is absorbed rapidly from the gastrointestinal tract, reaching peak plasma concentrations within 1-2 hours. It is metabolized primarily by the cytochrome P450 3A4 system and eliminated via renal and hepatic routes, giving it a terminal half-life of approximately 20 hours, which supports once-daily dosing. Onset of therapeutic benefit is generally observed after several weeks of continuous use, reflecting the time needed for chronic airway inflammation to subside. --- ## Conditions Treated with Roflumilast - **Severe COPD with chronic bronchitis** - Roflumilast reduces the rate of moderate and severe exacerbations, helping maintain lung function and improve quality of life. - **COPD patients with a history of frequent exacerbations** - The anti-inflammatory action targets the underlying pathophysiology that drives flare-ups, complementing bronchodilator regimens. These are the only indications formally approved by the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA). --- ## Is Roflumilast the Right Medication for You? Roflumilast is most appropriate for adults who: - Have a confirmed diagnosis of severe COPD (GOLD stage III-IV) with chronic bronchitis. - Experience two or more exacerbations per year despite optimal inhaled therapy (long-acting bronchodilators and inhaled corticosteroids). Clinical guidelines recommend roflumilast as an add-on therapy when inhaled treatments alone fail to control exacerbations. **Contraindications** include: - Severe liver impairment (Child-Pugh C). - Known hypersensitivity to roflumilast or any tablet excipients. Patients with moderate hepatic dysfunction, active tuberculosis, or a history of significant weight loss should use roflumilast only after careful risk-benefit assessment. Individuals who are pregnant, breastfeeding, or planning pregnancy should avoid the drug, as safety data are limited. --- ## Buying Roflumilast from [our online pharmacy](https://liabilis.com/order-roflumilast-online-en.html) ### Why Choose Our Service? Accessing roflumilast can be difficult due to insurance restrictions or limited pharmacy stock. Our platform offers a reliable alternative, ensuring you receive the medication you need without undue delay or expense. ### Quality & Safety Assurance We partner with licensed international pharmacies to ensure quality and authenticity. Every shipment is sourced from manufacturers that comply with recognized regulatory frameworks, and each batch undergoes third-party verification. ### Pricing & Access Because roflumilast is available as a generic, [our online pharmacy](https://liabilis.com/order-roflumilast-online-en.html) can provide it at a fraction of the branded price. This cost advantage makes long-term maintenance therapy more affordable for patients managing chronic respiratory disease. ### Discreet Delivery Orders are packaged in unmarked, tamper-evident containers and dispatched via express courier (typically within 7 days) or standard airmail (approximately 3 weeks). Secure handling protects your privacy from the moment the product leaves the warehouse until it reaches your doorstep. --- ## Use: Dosing, Missed Dose, Overdose - **Standard dosing**: The approved regimen is one tablet (500 µg) taken orally once daily, preferably in the morning with food to reduce gastrointestinal upset. The dosage listed in the source material-500 mg-is not reflective of the FDA-approved strength; patients should follow the 500 µg recommendation. - **Missed dose**: If a dose is forgotten, take it as soon as remembered unless it is near the time of the next scheduled dose. In that case, skip the missed tablet and resume the regular schedule; do not double-dose. - **Overdose**: Symptoms may include nausea, vomiting, severe diarrhea, and abdominal pain. Seek immediate medical attention or contact a poison control center. - **Precautions**: Avoid concomitant use of strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) as they may increase roflumilast concentrations. Alcohol can worsen gastrointestinal side effects; limit intake. Patients should not operate hazardous machinery until they know how roflumilast affects them personally. --- ## Safety Information ### ⚠️ Who Should Not Take Roflumilast - Individuals with severe hepatic impairment (Child-Pugh C). - Patients with a documented allergy to roflumilast or any tablet component. ### Common Side Effects - **Gastrointestinal**: Diarrhea, nausea, decreased appetite. These occur in up to 20 % of users and are usually mild to moderate. - **Weight loss**: A mean loss of 2-3 kg may be observed; nutritional counseling can mitigate this effect. - **Headache**: Reported in about 10 % of patients; typically transient. ### Serious Side Effects (Seek Immediate Medical Help) - **Severe depression or suicidal thoughts** - Roflumilast has a boxed warning for mood changes; discontinue and obtain urgent psychiatric evaluation if symptoms arise. - **Allergic reactions** - Hives, swelling of the face or throat, and difficulty breathing require emergency care. ### Drug & Food Interactions - **CYP3A4 inhibitors** (e.g., itraconazole, ritonavir) → increased plasma levels; dose adjustment may be needed. - **CYP3A4 inducers** (e.g., rifampin, carbamazepine) → reduced efficacy; avoid combination when possible. - **Strong acids or alkalines** - No significant interaction reported, but take with food to limit stomach irritation. --- ## Off-Label and Investigational Uses of Roflumilast - **Psoriasis** - Small pilot studies suggest PDE4 inhibition may reduce skin inflammation; larger trials are pending. - **Asthma** - Roflumilast has been explored as an add-on therapy for severe, steroid-dependent asthma, showing modest improvements in lung function. - **Inflammatory bowel disease** - Early-phase research evaluates its role in ulcerative colitis, targeting mucosal inflammation. These applications remain investigational and are not approved by regulatory agencies. Use for any off-label condition should occur only under direct supervision of a qualified healthcare professional. --- ## Storage & Handling - Store tablets at 20-25 °C (68-77 °F) in a dry place, protected from light. - Keep the container tightly closed to avoid moisture ingress. - Do not freeze; discard any tablets that have changed in appearance or texture. - Dispose of unused medication according to local hazardous waste regulations or return to a pharmacy take-back program. --- ## Frequently Asked Questions **Practical Use & Lifestyle** - **Can I travel internationally with roflumilast?** Yes, but keep the medication in its original packaging with a copy of the prescription (if required) and a doctor’s note describing its purpose. - **Should I take roflumilast with meals?** Taking the tablet with a meal reduces the risk of stomach upset and may improve absorption. - **Will roflumilast affect my ability to drive?** Most patients do not experience significant sedation; however, if you notice dizziness or visual changes, avoid operating vehicles until you are certain of its effects. **Product Information** - **What does a roflumilast tablet look like?** The generic tablet is typically white, round, and film-coated; exact imprint may vary by manufacturer. - **Can I split or crush a roflumilast tablet?** The tablet is not scored and should be swallowed whole to maintain consistent drug release. **Regulatory & Safety Nuances** - **Is roflumilast approved for use in children?** No, it is approved only for adult patients with COPD; safety and efficacy have not been established in pediatric populations. - **Will roflumilast appear on a standard drug test?** Roflumilast is not part of typical employment drug-screening panels, which focus on substances of abuse rather than prescription medications. - **Can pregnant women use roflumilast?** The drug is classified as Pregnancy Category C; it should be avoided unless the potential benefit justifies the possible risk to the fetus. **Scientific & Clinical Curiosity** - **When was roflumilast first approved?** The FDA approved roflumilast (Daliresp®) in 2011 for COPD maintenance therapy. - **How does roflumilast compare to oral steroids for COPD?** Unlike systemic corticosteroids, roflumilast targets a specific enzyme without causing the broad immunosuppression associated with steroids, resulting in a different side-effect profile. --- ## Glossary **Phosphodiesterase-4 (PDE4)** : An enzyme that breaks down cyclic AMP in inflammatory cells; inhibition raises cAMP levels and reduces inflammation. **Chronic Obstructive Pulmonary Disease (COPD)** : A progressive lung disease characterized by airflow limitation that is not fully reversible, commonly caused by smoking. **Bioequivalence** : A regulatory standard indicating that a generic drug delivers the same amount of active ingredient into the bloodstream as the brand-name product. **Boxed Warning** : The strongest FDA-mandated alert on a prescription label, indicating a serious or life-threatening risk. **Half-life** : The time required for the plasma concentration of a drug to decrease by 50 % after reaching steady state. --- ## Disclaimer The information provided about **Roflumilast** is for general knowledge only. It does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. **[our online pharmacy](https://liabilis.com/order-roflumilast-online-en.html)** offers access to **Roflumilast** for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.