--- title: Buy Generic Pentasa (Mesalamine) 400mg Pills description: Pentasa (Mesalamine) 400mg pills treat ulcerative colitis and Crohn's disease. Order this IBD medication from our reliable pharmacy. type: product language: en url: https://liabilis.com/order-pentasa-online-en.html availability: in_stock shipping: - type: Standard Airmail price: 10.00 currency: USD area: Worldwide time: 14-21 days - type: Tracked Express price: 30.00 currency: USD area: Worldwide tracking: true time: 5-9 days price_min: 56.99 price_max: 256.99 currency: USD offers: - name: 400mg x 30 pills price: 56.99 - name: 400mg x 60 pills price: 91.74 - name: 400mg x 90 pills price: 133.65 - name: 400mg x 120 pills price: 178.99 - name: 400mg x 180 pills price: 256.99 --- # Buy Generic Pentasa (Mesalamine) 400mg Pills Pentasa contains Mesalamine and works by reducing inflammation in the colon and rectum to treat ulcerative colitis and Crohn's disease. This anti-inflammatory medication helps control symptoms like diarrhea, rectal bleeding, and stomach pain. It is designed for adults with inflammatory bowel disease. Our pharmacy offers Pentasa in 400mg pill form for effective IBD management. ## Pricing and Options | Dosage | Pack Size | Price (USD) | Price Per Pill | Status | | :--- | :--- | :--- | :--- | :--- | | **400mg** | 30 pills | **$56.99** | $1.90 | In Stock | | **400mg** | 60 pills | **$91.74** | $1.53 | In Stock | | **400mg** | 90 pills | **$133.65** | $1.49 | In Stock | | **400mg** | 120 pills | **$178.99** | $1.49 | In Stock | | **400mg** | 180 pills | **$256.99** | $1.43 | In Stock | [Buy Now](https://liabilis.com/order-pentasa-online-en.html) ## Introduction Pentasa is a prescription medication that contains the active ingredient mesalamine, supplied as a 400 mg oral pill. It belongs to the 5-aminosalicylic acid (5-ASA) class of drugs, which are primarily used to treat inflammatory bowel disease (IBD). Pentasa is indicated for the long-term management of ulcerative colitis and for maintenance therapy in Crohn’s disease involving the ileum and right colon. Its formulation allows release of mesalamine throughout the gastrointestinal tract, providing consistent anti-inflammatory action. ## Quick Reference Facts ``` **Active Ingredient** : Mesalamine **Form** : Pill 400 mg **Primary Uses** : • Ulcerative colitis (induction & maintenance) • Crohn’s disease (maintenance of remission, ileocolonic involvement) ``` ## What is Pentasa? Pentasa is the generic version of medications containing the active compound mesalamine. It is marketed under several brand names worldwide, including Asacol, Salofalk, and Lialda. The drug is formulated as a pH-dependent, multi-matrix tablet that delivers mesalamine along the entire colon. Pentasa is manufactured by several licensed pharmaceutical companies that hold regulatory approval in multiple jurisdictions. Because it is a generic product, it must meet the same bio-equivalence standards as its brand-name counterparts, ensuring comparable therapeutic effect at a lower cost to patients. ## How Pentasa Works Mesalamine, the active moiety in Pentasa, exerts its effect by inhibiting cyclooxygenase and lipoxygenase pathways, which reduces the production of prostaglandins and leukotrienes-key mediators of intestinal inflammation. It also modulates nuclear factor-κB (NF-κB) activity, decreasing transcription of pro-inflammatory cytokines such as interleukin-1β and tumor necrosis factor-α. By acting locally on the mucosal surface of the colon, mesalamine limits systemic exposure and minimizes systemic side-effects. The tablet’s coating dissolves at pH ≈ 7, permitting drug release from the small intestine through the colon, which aligns the onset of action with the regions most affected by ulcerative colitis and Crohn’s disease. ## Conditions Treated with Pentasa - **Ulcerative colitis (induction of remission)** - Mesalamine reduces mucosal inflammation, helping patients achieve symptom control and mucosal healing. - **Ulcerative colitis (maintenance of remission)** - Continued therapy sustains remission, lowers relapse rates, and may reduce the need for corticosteroids. - **Crohn’s disease (maintenance of remission, ileocolonic disease)** - When disease is confined to the terminal ileum and right colon, mesalamine’s targeted release provides anti-inflammatory benefit while limiting systemic exposure. ## Is Pentasa the Right Medication for You? Pentasa is most appropriate for adults diagnosed with ulcerative colitis or Crohn’s disease involving the ileum or right colon who require long-term anti-inflammatory therapy. It is especially useful for patients who have responded to 5-ASA agents in the past or who prefer an oral regimen over rectal formulations. Contraindications include hypersensitivity to mesalamine or any salicylate, severe renal impairment (creatinine clearance < 30 mL/min), and active severe ulcerative colitis where rapid control with steroids or biologics is indicated. Caution is advised in patients with a history of pancreatitis, hepatic disease, or those taking nephrotoxic drugs, as mesalamine may exacerbate renal dysfunction. ## Buying Pentasa from [our online pharmacy](https://liabilis.com/order-pentasa-online-en.html) ### Why Choose Our Service? Accessing prescription medicines can be challenging due to high costs, limited pharmacy stock, or insurance restrictions. Our platform provides a reliable pathway to obtain Pentasa at prices close to the manufacturer’s wholesale cost, helping you stay on therapy without financial strain. ### Quality & Safety Assurance We partner with licensed international pharmacies to ensure quality and authenticity. Each shipment originates from facilities that comply with Good Manufacturing Practices (GMP) and are inspected by regulatory agencies such as the FDA or EMA. ### Pricing & Access Because Pentasa is a generic medication, it is substantially less expensive than brand-name 5-ASA products. Our pricing model reflects bulk purchasing power, allowing you to save up to 60 % compared with retail pharmacy rates. ### Discreet Delivery Orders are packaged in unmarked, tamper-evident containers and dispatched via express courier (typically within 7 days) or standard airmail (approximately 3 weeks). Your privacy is protected at every step of the fulfillment process. ## Use: Dosing, Missed Dose, Overdose - **Standard dosing** - Adult patients usually start with 400 mg taken three times daily (total 1,200 mg/day). For maintenance, doses may be increased to 800 mg three times daily (2,400 mg/day) based on clinical response. - **Missed dose** - If you remember within 2 hours, take the missed 400 mg tablet. If more than 2 hours have passed, skip the missed dose and resume your regular schedule. Do not double-dose. - **Overdose** - Symptoms may include nausea, vomiting, abdominal pain, or headache. Seek immediate medical attention or call your local poison control center. - **Administration tips** - Swallow tablets whole with a full glass of water; do not crush or chew. Take with or without food as tolerated. Avoid excessive alcohol, as it may increase gastrointestinal irritation. Operate machinery only after you know how Pentasa affects you. ## Safety Information ### ⚠️ Who Should Not Take Pentasa - Known allergy to mesalamine, sulfasalazine, or any salicylate. - Severe renal impairment (creatinine clearance < 30 mL/min). - Acute severe ulcerative colitis requiring hospitalization. - Pregnancy or breastfeeding without physician approval (risk-benefit must be evaluated). ### Common Side Effects - Headache (up to 15 % of users) - Nausea or mild abdominal discomfort (10-12 %) - Flatulence or loose stools (8-10 %) - These effects are usually transient; dose adjustment or symptomatic treatment may help. ### Serious Side Effects (Seek Immediate Medical Help) - **Renal dysfunction:** sudden rise in serum creatinine, decreased urine output. - **Pancreatitis:** severe upper abdominal pain radiating to the back, nausea, vomiting. - **Severe hypersensitivity:** rash, facial swelling, difficulty breathing. - **Blood dyscrasias:** unexplained bruising or bleeding, persistent fever. If any of these occur, discontinue Pentasa and contact a healthcare professional promptly. ### Drug & Food Interactions - **Nephrotoxic agents** (e.g., non-steroidal anti-inflammatory drugs, aminoglycosides): may increase risk of kidney injury. - **Anticoagulants** (warfarin): mesalamine can potentiate warfarin’s effect; monitor INR closely. - **Methotrexate:** concurrent use may raise methotrexate toxicity; adjust dosing under supervision. - **Live vaccines:** immunosuppressive effects of underlying disease may alter vaccine response; discuss with your physician. ## Off-Label and Investigational Uses of Pentasa - **Pouchitis** - Inflammation of an ileal pouch after colectomy; small observational studies suggest mesalamine can reduce symptom severity. - **Microscopic colitis** - Limited case series report improvement with oral mesalamine, though larger trials are needed. - **Prevention of colorectal cancer in IBD** - Long-term 5-ASA therapy is associated with a modest reduction in dysplasia risk; this remains an area of active research. These applications have not received regulatory approval and should only be pursued under specialist supervision. ## Storage & Handling - Store tablets at 20-25 °C (68-77 °F) in a dry place, away from direct sunlight and moisture. - Keep the container tightly closed; do not use if the blister pack is damaged. - Do not refrigerate. - Dispose of unused tablets according to local pharmacy guidelines or by returning them to a medication take-back program. ## Frequently Asked Questions **Practical Use & Lifestyle** - **Can I travel internationally with Pentasa?** Yes. Carry the medication in its original packaging with a copy of your prescription and a physician’s letter if required by customs. Keep tablets in your carry-on luggage to avoid temperature extremes. - **Should I avoid any specific foods while taking Pentasa?** No strict dietary restrictions exist, but high-fat meals may delay tablet dissolution. Maintaining a balanced diet helps overall disease control. - **Is it safe to exercise while on Pentasa?** Regular moderate exercise is encouraged. Monitor hydration, especially if you experience diarrhea, to prevent renal strain. **Product Information** - **What do Pentasa tablets look like?** Pentasa 400 mg tablets are round, white to off-white, and bear a debossed imprint of the dosage strength and manufacturer code. - **Can the tablets be split?** tablet’s coating is essential for pH-dependent release; splitting or crushing compromises efficacy and may increase side-effects. Do not split. **Regulatory & Safety Nuances** - **Will Pentasa appear on a drug test for athletes?** Mesalamine is not a prohibited substance under World Anti-Doping Agency (WADA) guidelines. However, athletes should verify with their governing body. - **Is Pentasa approved for use in seniors?** It is approved for adults of all ages, but renal function should be assessed regularly in older patients due to increased risk of nephrotoxicity. - **Can I purchase Pentasa if I live in a country where it isn’t marketed?** Import regulations vary. Our service complies with international shipping laws and provides documentation to support personal use import where permissible. **Scientific & Clinical Curiosity** - **How does Pentasa differ from other 5-ASA formulations?** Pentasa uses a multi-matrix system that releases mesalamine continuously from the small intestine to the colon, whereas some alternatives release the drug primarily in the distal colon. - **What major clinical trial supported Pentasa’s approval?** Large phase III trials demonstrated that Pentasa 2.4 g/day induced remission in approximately 45 % of ulcerative colitis patients, meeting the primary efficacy endpoint versus placebo. ## Glossary **5-ASA (5-Aminosalicylic Acid)** : A class of anti-inflammatory drugs that act locally on the gut lining to reduce ulceration and bleeding. **Bio-equivalence** : Demonstration that a generic product delivers the same amount of active ingredient into the bloodstream as the reference brand. **pH-dependent release** : A formulation characteristic that triggers drug dissolution at specific intestinal pH levels, targeting drug delivery to certain gut segments. ## Disclaimer The information provided about **Pentasa** is for general knowledge only. It does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. [our online pharmacy](https://liabilis.com/order-pentasa-online-en.html) offers access to **Pentasa** for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.