--- title: Buy Ofev (Nintedanib) 100mg Caps Online description: Ofev (Nintedanib) 100mg capsules treat idiopathic pulmonary fibrosis. Order from our secure online pharmacy for authentic quality and discreet service. type: product language: en url: https://liabilis.com/order-ofev-online-en.html availability: in_stock shipping: - type: Standard Airmail price: 10.00 currency: USD area: Worldwide time: 14-21 days - type: Tracked Express price: 30.00 currency: USD area: Worldwide tracking: true time: 5-9 days price_min: 192.99 price_max: 1378.99 currency: USD offers: - name: 100mg x 30 caps price: 192.99 - name: 100mg x 60 caps price: 329.99 - name: 100mg x 90 caps price: 454.99 - name: 100mg x 120 caps price: 550.99 - name: 100mg x 180 caps price: 1378.99 --- # Buy Ofev (Nintedanib) 100mg Caps Online Ofev, with Nintedanib and developed by Boehringer Ingelheim, is a kinase inhibitor for idiopathic pulmonary fibrosis (IPF). It slows lung function decline in adults. Also used for systemic sclerosis-associated ILD. Available as 100mg caps from our trusted online pharmacy. ## Pricing and Options | Dosage | Pack Size | Price (USD) | Price Per Pill | Status | | :--- | :--- | :--- | :--- | :--- | | **100mg** | 30 caps | **$192.99** | $6.43 | In Stock | | **100mg** | 60 caps | **$329.99** | $5.50 | In Stock | | **100mg** | 90 caps | **$454.99** | $5.06 | In Stock | | **100mg** | 120 caps | **$550.99** | $4.59 | In Stock | | **100mg** | 180 caps | **$1378.99** | $7.66 | In Stock | [Buy Now](https://liabilis.com/order-ofev-online-en.html) ## Introduction Ofev is a prescription medication whose active ingredient is nintedanib. It is supplied as a 100 mg hard capsule and belongs to the class of tyrosine-kinase inhibitors. The drug is approved to slow the decline in lung function for adults with idiopathic pulmonary fibrosis (IPF) and for treating systemic-sclerosis-associated interstitial lung disease (SSc-ILD). In oncology, nintedanib is used in combination with chemotherapy for certain advanced non-small-cell lung cancers. ## Quick Reference Facts **Active Ingredient** : Nintedanib **Form** : 100 mg hard capsule **Primary and Off-Label Uses** : • Idiopathic pulmonary fibrosis (IPF) : • Systemic-sclerosis-associated interstitial lung disease (SSc-ILD) : • Non-small-cell lung cancer (NSCLC) in combination therapy : • Investigational use in other fibrotic disorders (off-label) ## What is Ofev? Ofev is the generic version of medications that contain the active compound nintedanib. It is classified as a multi-targeted tyrosine-kinase inhibitor. The molecule was originally developed by Boehringer Ingelheim and received its first regulatory approval in the United States and Europe for IPF in 2014. While Ofev is the brand name used in many markets, the same active ingredient is marketed under other brand names such as Vargatef (in oncology) and various regional generics. Because this article focuses on the generic form, cost-saving and bio-equivalence to the branded products are emphasized. ## How Ofev Works Nintedanib blocks the intracellular signaling of several growth factor receptors, principally vascular endothelial growth factor receptors (VEGFR 1-3), fibroblast growth factor receptors (FGFR 1-3), and platelet-derived growth factor receptors (PDGFR α/β). By inhibiting these pathways, the drug reduces the proliferation, migration, and transformation of fibroblasts into collagen-producing myofibroblasts-a key driver of pulmonary fibrosis. In cancer therapy, the same anti-angiogenic effect limits tumor blood-vessel formation, enhancing the efficacy of cytotoxic agents. Oral absorption is moderate (≈4.5 % bioavailability), and steady-state concentrations are reached after 7 days of twice-daily dosing. Nintedanib is metabolized mainly by esterases; hepatic cytochrome-P450 enzymes play a minor role, which limits drug-drug interactions. Elimination occurs primarily via feces (≈93 %). ## Conditions Treated with Ofev - **Idiopathic Pulmonary Fibrosis (IPF)** Nintedanib slows the rate of forced vital capacity (FVC) decline, thereby preserving breathing capacity and quality of life in patients with this progressive, fatal lung disease. - **Systemic-Sclerosis-Associated Interstitial Lung Disease (SSc-ILD)** By attenuating fibroblast activation, Ofev reduces the progression of lung fibrosis in systemic sclerosis, a condition where pulmonary involvement is the leading cause of mortality. - **Non-Small-Cell Lung Cancer (NSCLC) - Combination Therapy** When combined with docetaxel, nintedanib improves overall survival in patients with advanced disease after first-line chemotherapy failure, owing to its anti-angiogenic properties. ## Is Ofev the Right Medication for You? Ofev is appropriate for adults diagnosed with IPF or SSc-ILD who have measurable decline in lung function and for oncologists prescribing a second-line regimen for NSCLC. Patients who can tolerate oral medication twice daily and have adequate liver function (Child-Pugh A) are typical candidates. Contraindications include severe hepatic impairment, pregnancy, lactation, and known hypersensitivity to nintedanib or any capsule excipients. Individuals with a history of significant cardiovascular events or uncontrolled bleeding disorders require careful assessment before initiation. ## Buying Ofev from [our online pharmacy](https://liabilis.com/order-ofev-online-en.html) ### Why Choose Our Service? Our platform offers a streamlined way to obtain Ofev when local pharmacies face shortages or when price differentials make treatment unaffordable. We understand that chronic lung disease demands reliable, uninterrupted access to medication. ### Quality & Safety Assurance We partner with licensed international pharmacies to ensure quality and authenticity. Each shipment is sourced from facilities that follow Good Manufacturing Practice (GMP) standards and are inspected by regulatory authorities. ### Pricing & Access Because Ofev is supplied in its generic form, the price is close to the manufacturer’s wholesale cost, delivering substantial savings compared with branded equivalents. Our network also reaches regions where the medication may be unavailable through conventional channels. ### Discreet Delivery Orders are packaged in unmarked, tamper-evident containers and dispatched with express shipping that typically arrives within 7 days, or via standard airmail in approximately 3 weeks. Privacy is maintained throughout the fulfillment process. ## Use: Dosing, Missed Dose, Overdose - **Standard Dosing** The usual regimen for IPF and SSc-ILD is 150 mg (one 100 mg capsule plus a half capsule) taken twice daily with food. Dose reduction to 100 mg twice daily is recommended if patients experience intolerable gastrointestinal side effects. In NSCLC combination therapy, the same twice-daily schedule is used alongside chemotherapy. - **Missed Dose** If a dose is missed and the next scheduled dose is more than 8 hours away, take the missed dose as soon as remembered. Do not double-dose to compensate for a missed tablet. - **Overdose** Suspected overdose should be treated as a medical emergency. Contact emergency services or a poison-control center immediately. Supportive care may include monitoring of liver enzymes, electrolytes, and hydration status. - **Practical Precautions** - Take Ofev with food to lessen gastrointestinal irritation. - Avoid excessive alcohol consumption, which can increase liver enzyme elevations. - Refrain from operating heavy machinery until you know how the medication affects you, as dizziness or fatigue may occur. ## Safety Information ### ⚠️ Who Should Not Take Ofev - Patients with severe hepatic impairment (Child-Pugh B or C). - Pregnant or breastfeeding women. - Individuals with known hypersensitivity to nintedanib or any capsule components. ### Common Side Effects - **Diarrhea** (up to 60 %): Usually mild to moderate; hydration and antidiarrheal agents are recommended. - **Nausea and abdominal pain** (30-40 %): May improve with food intake. - **Elevated liver enzymes** (ALT/AST): Monitor liver function tests every 4-6 weeks during the first 3 months. ### Serious Side Effects (Seek Immediate Medical Help) - **Severe hepatic injury** (jaundice, right-upper-quadrant pain). - **Bleeding events** (gastrointestinal hemorrhage, hemoptysis). - **Cardiovascular complications** (myocardial infarction, ischemic stroke) especially in patients with existing risk factors. ### Drug & Food Interactions - **Strong CYP3A4 inhibitors** (e.g., ketoconazole, clarithromycin) - may increase nintedanib exposure; dose adjustment required. - **CYP3A4 inducers** (e.g., rifampicin, carbamazepine) - may reduce efficacy; avoid if possible. - **P-glycoprotein inhibitors** (e.g., verapamil) - can raise plasma levels. - **Anticoagulants/antiplatelet agents** - heightened bleeding risk; monitor INR or bleeding signs closely. ## Off-Label and Investigational Uses of Ofev Clinical studies have explored nintedanib for liver fibrosis, renal fibrosis, and certain autoimmune conditions such as rheumatoid arthritis, reflecting its broad anti-fibrotic potential. Small pilot trials in chronic kidney disease suggest a modest slowdown of eGFR decline, but these findings are not yet validated in large-scale Phase III studies. Use in these contexts remains off-label; any such application should occur only under specialist supervision and within a clinical-trial framework. ## Storage & Handling - Store capsules at 20-25 °C (68-77 °F); excursions permitted between 15-30 °C. - Keep the container tightly closed and protect from moisture and direct sunlight. - Do not use beyond the printed expiry date; discard any compromised capsules. - For safe disposal, follow local pharmacy take-back programs or incineration guidelines. ## Frequently Asked Questions **Practical Use & Lifestyle** - **Can I travel internationally with Ofev?** Yes, but carry the medication in its original labeled container, accompanied by a copy of the prescription and a doctor’s letter if required by customs. - **Should I avoid grapefruit while taking Ofev?** Grapefruit juice can inhibit CYP3A4 enzymes and may modestly increase nintedanib levels. It is prudent to limit consumption and discuss any dietary concerns with your pharmacist. - **Is it safe to exercise while on Ofev?** Moderate aerobic activity is generally safe. However, if you experience dizziness, severe fatigue, or unexplained shortness of breath, pause exercise and seek medical advice. **Product & Formulation Details** - **What does an Ofev capsule look like?** The 100 mg capsule is opaque, white, and oblong with a smooth gelatin coating; the imprint typically reads “NIN 100”. - **Can the capsule be split or crushed?** Splitting is not recommended because the dose is not scored, and crushing may affect absorption and increase gastrointestinal irritation. - **Are there any inactive ingredients I should be aware of?** The capsule contains lactose, magnesium stearate, and microcrystalline cellulose. Patients with severe lactose intolerance should consult their clinician. **Regulatory & Safety Nuances** - **Will Ofev show up on a standard drug test?** Nintedanib is not screened for in routine employment drug panels, as it is not a controlled substance. - **Is Ofev safe for elderly patients?** Age alone is not a contraindication, but older adults often have reduced hepatic function and may require dose adjustments; regular liver monitoring is essential. - **Can I purchase Ofev without a prescription?** No. Ofev is a prescription-only medication in all jurisdictions; a valid prescription is required for any legal purchase. **Scientific & Clinical Curiosity** - **What was the pivotal trial that led to Ofev’s approval for IPF?** The INPULSIS-1 and INPULSIS-2 Phase III trials demonstrated a 50 % reduction in the annual rate of FVC decline compared with placebo, forming the basis for regulatory approval. - **How does Ofev differ from earlier anti-fibrotic agents?** Unlike pirfenidone, which has an uncertain target, nintedanib’s inhibition of multiple tyrosine-kinase pathways provides a broader mechanistic approach to blocking fibroblast activity. ## Glossary **Tyrosine-Kinase Inhibitor** : A drug that blocks enzymes (tyrosine kinases) responsible for signaling pathways that promote cell growth, division, and fibrosis. **Interstitial Lung Disease** : A heterogeneous group of pulmonary disorders characterized by inflammation and scarring of the lung interstitium, leading to reduced gas exchange. **Bioavailability** : The proportion of an orally administered drug that reaches systemic circulation unchanged. **Hepatotoxicity** : Liver injury caused by chemical substances, manifesting as elevated enzymes or functional impairment. ## Disclaimer The information presented about Ofev is intended for general educational purposes and does not substitute professional medical advice. Treatment decisions, including any off-label applications, must be made under the guidance of a qualified healthcare professional. Readers are presumed to be adults capable of making informed health choices. Our pharmacy service provides access to Ofev for individuals who encounter limited availability, insurance barriers, or who seek cost-effective generic alternatives. Always discuss with your clinician before initiating, modifying, or discontinuing any medication.