--- title: Buy Glucophage SR Metformin 500mg Pills Online description: Glucophage SR is a sustained-release Metformin formulation for type 2 diabetes management. Order 500mg pills from our secure online pharmacy. type: product language: en url: https://liabilis.com/order-glucophage-sr-online-en.html availability: in_stock shipping: - type: Standard Airmail price: 10.00 currency: USD area: Worldwide time: 14-21 days - type: Tracked Express price: 30.00 currency: USD area: Worldwide tracking: true time: 5-9 days price_min: 36.99 price_max: 143.99 currency: USD offers: - name: 500mg x 30 Pills price: 36.99 - name: 500mg x 60 Pills price: 66.99 - name: 500mg x 90 Pills price: 89.99 - name: 500mg x 120 Pills price: 108.99 - name: 500mg x 180 Pills price: 143.99 --- # Buy Glucophage SR Metformin 500mg Pills Online Glucophage SR is the sustained-release formulation of Metformin hydrochloride, designed to provide gradual medication release throughout the day for consistent blood sugar control. This extended-release version offers the advantage of once-daily dosing for many patients, improving convenience while maintaining effectiveness for type 2 diabetes management. Our online pharmacy provides reliable access to Glucophage SR in 500mg pill strength with verified quality assurance and consistent delivery. ## Pricing and Options | Dosage | Pack Size | Price (USD) | Price Per Pill | Status | | :--- | :--- | :--- | :--- | :--- | | **500mg** | 30 Pills | **$36.99** | $1.23 | In Stock | | **500mg** | 60 Pills | **$66.99** | $1.12 | In Stock | | **500mg** | 90 Pills | **$89.99** | $1.00 | In Stock | | **500mg** | 120 Pills | **$108.99** | $0.91 | In Stock | | **500mg** | 180 Pills | **$143.99** | $0.80 | In Stock | [Buy Now](https://liabilis.com/order-glucophage-sr-online-en.html) ## Introduction Glucophage SR is a sustained-release tablet that contains the active ingredient metformin. It belongs to the biguanide class of oral antidiabetic agents and is formulated to release metformin slowly over several hours after ingestion. In most jurisdictions Glucophage SR is prescribed for adults with type 2 diabetes mellitus to improve blood glucose control. The tablet is available in a 500 mg strength and is taken orally. Metformin also has recognized secondary uses, such as adjunct therapy for polycystic ovary syndrome (PCOS) and for certain individuals with pre-diabetes, though these are off-label in many regions. ## Quick Reference Facts **Active Ingredient** : Metformin **Form** : Pill 500 mg **Primary Uses** : • Management of type 2 diabetes mellitus in adults : • Adjunct treatment of polycystic ovary syndrome (off-label) ## What is Glucophage SR? Glucophage SR is the generic version of medications containing the active compound metformin. It is marketed under brand names such as Glucophage, Glucophage XR, and other extended-release metformin products. As a generic formulation, Glucophage SR must demonstrate bioequivalence to the reference brand, meaning it delivers the same amount of active drug into the bloodstream under comparable conditions. The tablet is manufactured by licensed pharmaceutical companies that follow Good Manufacturing Practices (GMP). Because it is a generic, it offers the therapeutic benefits of metformin at a lower cost than brand-name equivalents. ## How Glucophage SR Works Metformin primarily reduces hepatic glucose production through inhibition of gluconeogenesis. It also enhances peripheral insulin sensitivity, allowing muscle and adipose tissue to take up glucose more effectively. In addition, metformin modestly slows intestinal absorption of glucose after meals. The sustained-release (SR) formulation spreads the drug’s release over 8-12 hours, producing steadier plasma concentrations and reducing the peak-related gastrointestinal side effects commonly seen with immediate-release tablets. Metformin is not metabolized appreciably; it is excreted unchanged by the kidneys, so renal function is a key determinant of dosing and safety. ## Conditions Treated with Glucophage SR - **Type 2 Diabetes Mellitus** - Metformin lowers fasting plasma glucose and HbA1c by decreasing hepatic glucose output and improving insulin sensitivity, addressing core pathophysiology of the disease. - **Prediabetes (Off-label)** - Some guidelines suggest metformin for high-risk individuals because it can delay progression to overt diabetes by improving glucose tolerance. - **Polycystic Ovary Syndrome (PCOS) (Off-label)** - Metformin helps reduce insulin resistance, which can lower androgen levels and improve ovulatory function in many patients. ## Is Glucophage SR the Right Medication for You? Glucophage SR is most appropriate for adult patients with type 2 diabetes who have adequate renal function (eGFR ≥ 45 mL/min/1.73 m²) and who are not pregnant or breastfeeding. It is especially useful for individuals who experience gastrointestinal irritation with immediate-release metformin, as the SR formulation tends to be better tolerated. Contraindications include severe renal impairment (eGFR < 30 mL/min), known hypersensitivity to metformin, acute or chronic metabolic acidosis, and conditions that predispose to lactic acidosis (e.g., severe heart failure, hepatic disease). Patients with a history of lactic acidosis, uncorrected dehydration, or recent iodinated contrast studies should avoid metformin until appropriate renal recovery is confirmed. ## Buying Glucophage SR from [our online pharmacy](https://liabilis.com/order-glucophage-sr-online-en.html) ### Why Choose Our Service? Accessing affordable, high-quality medication can be difficult when local pharmacies have limited stock or higher brand-name prices. Our platform streamlines the purchasing process, offering a discreet, reliable way to obtain Glucophage SR at near-manufacturer cost. ### Quality & Safety Assurance We partner with licensed international pharmacies to ensure quality and authenticity. Each shipment is sourced from suppliers that comply with recognized regulatory frameworks and undergo rigorous verification. ### Pricing & Access Because Glucophage SR is a generic, the price is substantially lower than brand equivalents such as Glucophage XR. Our service makes this cost saving transparent, helping patients manage long-term therapy without financial strain. ### Discreet Delivery Orders are packaged in unmarked, tamper-evident containers and dispatched with express delivery typically within 7 days or via standard airmail in approximately 3 weeks. Privacy is maintained throughout the fulfillment process. ## Use: Dosing, Missed Dose, Overdose - **Standard Dosing** - Begin with one 500 mg tablet taken with the evening meal. The dose may be increased 500 mg weekly, based on tolerance and glycaemic response, up to a maximum of 200 (usually divided into two doses). - **Missed Dose** - If a dose is forgotten, take it as soon as remembered unless it is within 8 hours of the next scheduled dose; in that case, skip the missed tablet and resume the regular regimen. Do not double-dose. - **Overdose** - Signs may include severe gastrointestinal distress, lethargy, or respiratory difficulty. Seek emergency medical attention immediately; treatment focuses on supportive care and monitoring for lactic acidosis. - **Administration Tips** - Swallow tablets whole; do not crush or chew. Take with food to minimize stomach upset. Avoid excessive alcohol, as it can increase the risk of lactic acidosis. Caution is advised when operating machinery until you know how metformin affects you. ## Safety Information ### ⚠️ Who Should Not Take Glucophage SR - Severe renal impairment (eGFR < 30 mL/min/1.73 m²) - Acute or chronic metabolic acidosis, including diabetic ketoacidosis - Known hypersensitivity to metformin or any tablet excipients - Pregnant or breastfeeding women (unless specifically prescribed by a physician) ### Common Side Effects - Gastro-intestinal upset (nausea, diarrhea, abdominal discomfort) - usually transient and dose-related - Metallic taste in the mouth - Mild weight loss - often beneficial in type 2 diabetes ### Serious Side Effects (Seek Immediate Medical Help) - Lactic acidosis: rapid breathing, muscle pain, abdominal pain, dizziness, severe fatigue - Severe skin reactions (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis) - Hepatotoxicity: jaundice, dark urine, upper-right abdominal pain ### Drug & Food Interactions - **Iodinated contrast agents** - temporarily discontinue metformin before and after imaging that uses contrast, especially if renal function is compromised. - **Alcohol** - excessive intake increases lactic acidosis risk. - **Cimetidine, trimethoprim, and certain diuretics** - may reduce renal clearance of metformin, raising plasma levels. - **Beta-blockers, corticosteroids, thiazide diuretics** - can diminish glucose-lowering effect, requiring closer monitoring. ## Off-Label and Investigational Uses of Glucophage SR - **Polycystic Ovary Syndrome (PCOS)** - Clinical studies show metformin can improve insulin resistance and restore ovulation in many women with PCOS, though it is not FDA-approved for this indication. - **Obesity Management** - Metformin has modest weight-loss effects and is sometimes used adjunctively in weight-control programs, but efficacy varies. - **Non-Alcoholic Fatty Liver Disease (NAFLD)** - Small trials suggest metformin may improve liver enzyme profiles; however, it remains investigational. All off-label applications should only be pursued under direct supervision of a qualified healthcare professional. ## Storage & Handling - Store tablets at 20-25 °C (68-77 °F) in a dry place, protected from moisture and light. - Keep container tightly closed; do not use past the printed expiration date. - Dispose of unused tablets according to local pharmacy-take-back programs or household waste guidelines if take-back is unavailable. ## Frequently Asked Questions **Practical Use & Lifestyle** - **Can I travel internationally with Glucophage SR?** Yes, but keep the medication in its original container with a copy of the prescription or a physician’s letter. Check the destination country’s import regulations before departure. - **Should I take Glucophage SR with breakfast or dinner?** It is usually taken with the evening meal to reduce nighttime hepatic glucose production and to improve tolerability. Adjust timing only under medical guidance. - **Is it safe to drink alcohol while on metformin?** Moderate alcohol consumption is permissible, but excessive intake heightens the risk of lactic acidosis. Discuss your drinking habits with your clinician. **Product Information** - **What do Glucophage SR tablets look like?** The 500 mg extended-release tablets are typically white, oval-shaped, and film-coated, bearing the imprint “500 SR”. Tablet appearance may vary slightly by manufacturer. - **Can I split a Glucophage SR tablet?** No. The sustained-release matrix is designed to dissolve slowly; cutting or crushing the tablet destroys this mechanism and may increase side-effects. **Safety & Regulations** - **Will Glucophage SR show up on a drug test for athletes?** Metformin is not a prohibited substance under major anti-doping agencies, so it should not cause a positive test result. - **Is Glucophage SR approved for use in patients over 80 years old?** Metformin can be used in older adults if renal function is adequate, but clinicians often start at a lower dose and monitor closely for gastrointestinal intolerance. **Scientific & Clinical Curiosity** - **Why does the SR formulation cause fewer stomach problems?** By releasing metformin gradually, peak plasma concentrations are lower, reducing the direct irritant effect on the gastrointestinal lining. - **How does metformin differ from insulin-secretagogues?** Metformin does not stimulate insulin release; instead, it improves the body’s response to existing insulin and lowers hepatic glucose output, decreasing the risk of hypoglycaemia. ## Glossary **Bioavailability** : The proportion of an administered dose that reaches systemic circulation in an active form. **Gluconeogenesis** : The metabolic pathway through which the liver generates glucose from non-carbohydrate substrates, a process inhibited by metformin. **Extended-Release (SR)** : A dosage form designed to release the active ingredient slowly over time, providing prolonged therapeutic effect and reducing dosing frequency. ## Disclaimer The material presented about **Glucophage SR** is intended for general educational purposes and does not substitute personalized medical advice. Treatment decisions, including any off-label applications, should be made under the guidance of a qualified healthcare professional. Readers are presumed to be responsible adults capable of making informed health choices. [our online pharmacy](https://liabilis.com/order-glucophage-sr-online-en.html) provides a route to obtain **Glucophage SR** for individuals who may encounter limited availability, insurance barriers, or who are seeking cost-effective generic alternatives. Always discuss with your physician before initiating, modifying, or stopping any medication.