--- title: Buy Gleevec (Imatinib) 100mg/400mg Pills Online description: Gleevec (Imatinib) 100mg/400mg pills treat chronic myeloid leukemia and gastrointestinal stromal tumors in adults. Order from our secure online pharmacy for verified quality and reliable delivery. type: product language: en url: https://liabilis.com/order-gleevec-online-en.html availability: in_stock shipping: - type: Standard Airmail price: 10.00 currency: USD area: Worldwide time: 14-21 days - type: Tracked Express price: 30.00 currency: USD area: Worldwide tracking: true time: 5-9 days price_min: 72.99 price_max: 839.99 currency: USD offers: - name: 100mg x 10 pills price: 72.99 - name: 100mg x 20 pills price: 127.99 - name: 100mg x 30 pills price: 164.99 - name: 100mg x 60 pills price: 274.99 - name: 400mg x 10 pills price: 182.99 - name: 400mg x 20 pills price: 311.99 - name: 400mg x 30 pills price: 439.99 - name: 400mg x 60 pills price: 839.99 --- # Buy Gleevec (Imatinib) 100mg/400mg Pills Online Gleevec, containing the active ingredient imatinib, is a targeted therapy developed by Novartis. It treats chronic myeloid leukemia, acute lymphoblastic leukemia, and gastrointestinal stromal tumors. Designed for adults managing these conditions, it helps control cancer cell growth. Our online pharmacy offers a reliable way to access Gleevec in 100mg and 400mg pills. ## Pricing and Options | Dosage | Pack Size | Price (USD) | Price Per Pill | Status | | :--- | :--- | :--- | :--- | :--- | | **100mg** | 10 pills | **$72.99** | $7.30 | In Stock | | **100mg** | 20 pills | **$127.99** | $6.40 | In Stock | | **100mg** | 30 pills | **$164.99** | $5.50 | In Stock | | **100mg** | 60 pills | **$274.99** | $4.58 | In Stock | | **400mg** | 10 pills | **$182.99** | $18.30 | In Stock | | **400mg** | 20 pills | **$311.99** | $15.60 | In Stock | | **400mg** | 30 pills | **$439.99** | $14.67 | In Stock | | **400mg** | 60 pills | **$839.99** | $14.00 | In Stock | [Buy Now](https://liabilis.com/order-gleevec-online-en.html) ## Introduction Gleevec is a medication that contains the active compound imatinib. It is supplied as oral pills in strengths of 100 mg and 400 mg. Imatinib belongs to the class of tyrosine-kinase inhibitors and is primarily used to treat certain cancers driven by abnormal kinase activity. The drug’s main approved uses include chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). In some regions it is also indicated for Philadelphia-chromosome-positive acute lymphoblastic leukemia (Ph⁺ ALL) and certain other rare malignancies. --- ## Quick Reference Facts **Active Ingredient** : Imatinib **Form** : pill 100 mg | 400 mg **Primary and Off-Label Uses** : • Chronic myeloid leukemia (CML) : • Gastrointestinal stromal tumor (GIST) : • Philadelphia-positive acute lymphoblastic leukemia (Ph⁺ ALL) : • Dermatofibrosarcoma protuberans (off-label) : • Systemic mastocytosis (off-label) --- ## What is Gleevec? Gleevec is the generic version of medications that contain the active compound imatinib. Imatinib functions as a selective inhibitor of several tyrosine kinases, most notably BCR-ABL, c-KIT, and PDGFR. The drug was originally discovered by researchers at Ciba-Geigy (now part of Novartis) and was first approved by the U.S. Food and Drug Administration (FDA) in 2001 for the treatment of chronic myeloid leukemia. While the brand name Gleevec (also known as Glivec in some countries) is widely recognized, the generic formulation delivers the same therapeutic benefit at a lower cost. Because it is a generic product, it is considered bioequivalent to the brand-named versions and can be prescribed interchangeably by clinicians. --- ## How Gleevec Works Imatinib blocks the activity of specific tyrosine kinases by binding to the ATP-binding site of the enzyme. In CML, the BCR-ABL fusion protein drives uncontrolled cell proliferation; imatinib’s inhibition halts this signal, allowing normal blood cell development to resume. In GIST, the drug targets mutant c-KIT or PDGFRα receptors that promote tumor growth. By preventing phosphorylation of downstream signaling proteins, imatinib reduces cell division and induces apoptosis in malignant cells. Pharmacokinetically, imatinib is rapidly absorbed after oral administration, reaching peak plasma concentrations within 2-4 hours. It is metabolized primarily by the hepatic enzyme CYP3A4 and has an elimination half-life of approximately 18 hours, supporting once-daily dosing for most indications. Food may modestly increase absorption, but the medication can be taken with or without meals. The drug’s clearance is largely hepatic; renal excretion accounts for a smaller fraction of the dose. --- ## Conditions Treated with Gleevec - **Chronic Myeloid Leukemia (CML)** - Imatinib targets the BCR-ABL tyrosine-kinase produced by the Philadelphia chromosome. Inhibiting this enzyme stops the proliferative signal that characterizes CML, leading to durable cytogenetic and molecular remissions in the majority of patients. - **Gastrointestinal Stromal Tumor (GIST)** - Many GISTs harbor activating mutations in c-KIT or PDGFRα. Imatinib binds these mutant receptors, suppressing tumor growth and often producing tumor shrinkage, which can make surgery feasible or serve as long-term disease control. - **Philadelphia-positive Acute Lymphoblastic Leukemia (Ph⁺ ALL)** - The same BCR-ABL fusion present in CML drives leukemic proliferation in Ph⁺ ALL. Adding imatinib to chemotherapy regimens improves remission rates and overall survival compared with chemotherapy alone. - **Dermatofibrosarcoma Protuberans (DFSP) - Off-Label** - DFSP often expresses the COL1A1-PDGFB fusion gene, rendering the tumor sensitive to PDGFR inhibition. Clinical case series have documented tumor regression with imatinib, though it remains an off-label option. - **Systemic Mastocytosis - Off-Label** - Mutations in c-KIT (especially D816V) underpin many forms of mastocytosis. Imatinib can reduce mast cell burden in patients whose disease is driven by imatinib-sensitive KIT mutations, but it is not approved for this use. --- ## Is Gleevec the Right Medication for You? Gleevec is appropriate for adult patients diagnosed with BCR-ABL-positive CML, unresectable or metastatic GIST harboring KIT/PDGFRα mutations, and Ph⁺ ALL when used in combination with chemotherapy. Ideal candidates are individuals with adequate liver function (since metabolism is CYP3A4-dependent) and no known hypersensitivity to imatinib or its excipients. The medication is especially recommended when rapid disease control is needed, as its targeted mechanism often yields quick hematologic and cytogenetic responses. Patients with significant cardiac arrhythmias, uncontrolled infections, or severe hepatic impairment may be unsuitable candidates. Additionally, concurrent use of strong CYP3A4 inhibitors (e.g., ketoconazole) can raise imatinib levels and increase toxicity risk, making dose adjustment or alternative therapy necessary. Clinical judgment, based on disease stage, comorbidities, and laboratory parameters, determines suitability. --- ## Buying Gleevec from [our online pharmacy](https://liabilis.com/order-gleevec-online-en.html) ### Why Choose Our Service? Accessing imatinib can be challenging due to cost or limited local stock. Our platform offers a straightforward way to obtain the generic formulation, helping patients avoid the premium price of brand-name alternatives while maintaining therapeutic quality. ### Quality & Safety Assurance We partner with licensed international pharmacies to ensure quality and authenticity. Every batch of Gleevec is sourced from manufacturers that comply with Good Manufacturing Practice (GMP) standards and are inspected by regulatory agencies. ### Pricing & Access Because Gleevec is a generic product, its price is typically close to the manufacturer’s wholesale cost, delivering substantial savings compared with brand equivalents. Our service also makes the medication reachable for patients in regions where local pharmacies may not stock it regularly. ### Discreet Delivery Orders are packaged in unmarked, tamper-evident envelopes and shipped with standard or express options. Express delivery usually arrives within 7 days, while standard international airmail takes approximately 3 weeks, ensuring privacy and timely receipt without drawing attention. --- ## Use: Dosing, Missed Dose, Overdose - **Standard Dosing** - CML (chronic phase): 400 mg once daily. - Accelerated or blast phase CML: 400 mg twice daily may be considered. - GIST: 400 mg once daily; some patients may require 400 mg twice daily for resistant disease. - Pediatric or dose-adjusted regimens follow specialist guidance. - **Missed Dose** - If a dose is forgotten and the scheduled time is less than 6 hours away, take the missed tablet as soon as remembered. - If more than 6 hours have passed, skip the missed dose and resume the regular dosing schedule. Do not double-dose to compensate. - **Overdose** - Signs may include severe nausea, vomiting, dizziness, or hypotension. - Immediate medical attention is advised; supportive care and gastric decontamination may be employed in a clinical setting. - **Practical Precautions** - Imatinib can be taken with or without food; consistency helps maintain steady blood levels. - Avoid excessive alcohol, as it can worsen liver toxicity. - Do not operate heavy machinery or drive until you know how the medication affects you, especially during the first weeks of therapy. --- ## Safety Information ### ⚠️ Who Should Not Take Gleevec - Patients with known hypersensitivity to imatinib or any tablet excipients. - Individuals with severe hepatic impairment (Child-Pugh C) due to increased exposure risk. - Patients receiving concurrent strong CYP3A4 inhibitors without dose adjustment, as this can precipitate toxic plasma concentrations. ### Common Side Effects - **Gastrointestinal:** Nausea, diarrhea, abdominal pain - usually mild and improve with continued therapy. - **Edema:** Peripheral swelling, often manageable with elevation and reduced salt intake. - **Muscle Cramps & Fatigue:** Common early in treatment; hydration and gentle exercise may help. ### Serious Side Effects (Seek Immediate Medical Help) - **Hepatotoxicity:** Jaundice, dark urine, elevated liver enzymes - requires urgent evaluation. - **Severe Myelosuppression:** Neutropenia, thrombocytopenia, or anemia presenting as fever, easy bruising, or fatigue. - **Cardiac Events:** QT-interval prolongation, arrhythmias, or sudden chest pain. ### Drug & Food Interactions - **CYP3A4 Inhibitors** (e.g., ketoconazole, clarithromycin, grapefruit juice) - increase imatinib plasma levels; dose reduction may be needed. - **CYP3A4 Inducers** (e.g., rifampin, St John’s wort) - decrease drug exposure, potentially reducing efficacy. - **Antacids** - may affect absorption; separate administration by at least 2 hours. - **Vaccines** - live attenuated vaccines should be avoided during significant immunosuppression caused by imatinib. --- ## Off-Label and Investigational Uses of Gleevec Clinical investigations have explored imatinib for a variety of malignancies beyond its approved spectrum. Notable off-label applications include: - **Dermatofibrosarcoma Protuberans (DFSP):** Small case series demonstrate tumor regression when imatinib targets the COL1A1-PDGFB fusion. - **Systemic Mastocytosis:** In patients with imatinib-sensitive KIT mutations (non-D816V), disease burden may decrease; however, the D816V mutation, common in systemic mastocytosis, is resistant. - **Hypereosinophilic Syndromes:** Some reports indicate hematologic improvement when eosinophilia is driven by PDGFR-α rearrangements. These uses remain investigational and lack formal regulatory approval. Treatment should occur only under specialist supervision, with informed consent regarding uncertain benefits and potential risks. --- ## Storage & Handling - Store tablets at controlled room temperature (20 °C - 25 °C). - Protect from excess moisture and direct sunlight. - Keep the container tightly closed; discard any tablets that are discolored or crumbling. - Do not use after the printed expiry date. - For disposal, follow local pharmaceutical waste guidelines or return unused medication to a pharmacy-based take-back program. --- ## Frequently Asked Questions **Practical Use & Lifestyle** - **Can I travel internationally with Gleevec?** Yes, but carry the medication in its original packaging with the prescription label visible. Some countries require a doctor's note; check local regulations before departure. - **Does grapefruit juice affect Gleevec?** Grapefruit inhibits CYP3A4, which can raise imatinib concentrations and increase side-effect risk. It is advisable to limit or avoid grapefruit while on therapy. - **Should I take Gleevec at the same time each day?** Consistent daily timing helps maintain stable blood levels and reduces the likelihood of missed doses. **Product Information** - **What do Gleevec tablets look like?** The 100 mg tablets are round, white, and film-coated; the 400 mg tablets are larger, round, and film-coated with a distinct imprint indicating strength. - **Can the tablets be split or crushed?** Splitting is not recommended because the film coating protects the drug from degradation. If swallowing is difficult, discuss alternative formulations with your pharmacist. **Safety & Regulations** - **Will Gleevec appear on a standard drug test?** Imatinib is not typically screened for in routine workplace drug tests, which focus on substances of abuse. - **Is Gleevec safe for elderly patients?** Elderly individuals may have reduced hepatic function and altered drug metabolism, increasing the risk of toxicity. Dose adjustments and close monitoring are often required. **Scientific & Clinical Curiosity** - **What was the pivotal trial that led to Gleevec’s approval?** The IRIS (International Randomized Study of Imatinib vs. Interferon + Cytarabine) trial demonstrated superior complete cytogenetic response rates in newly diagnosed CML patients, forming the basis for FDA approval. - **How does Gleevec compare with newer TKIs for CML?** Second-generation TKIs (e.g., dasatinib, nilotinib) have higher potency and may achieve faster molecular responses, but imatinib remains a standard first-line option due to its long-term safety profile and lower cost. --- ## Glossary **Tyrosine-Kinase Inhibitor (TKI)** : A class of drugs that block enzymes responsible for signaling pathways that promote cell growth and division. **BCR-ABL Fusion Protein** : An abnormal enzyme produced by the Philadelphia chromosome; it drives unregulated proliferation in chronic myeloid leukemia. **CYP3A4** : A liver enzyme that metabolizes many medications, including imatinib; its activity can be altered by other drugs or foods. **Pharmacokinetics** : The study of how a drug is absorbed, distributed, metabolized, and eliminated by the body. **Off-Label Use** : Administration of a medication for an indication, dosage, or patient group that has not received formal regulatory approval. --- ## Disclaimer The information provided about **Gleevec** is for general knowledge only. It does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. [our online pharmacy](https://liabilis.com/order-gleevec-online-en.html) offers access to **Gleevec** for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.