--- title: Buy Colofac (Mebeverin) 135mg Pills Online description: Colofac (Mebeverin) 135mg Pills relieve irritable bowel syndrome symptoms. Order from our secure online pharmacy for trusted IBS treatment and reliable delivery. type: product language: en url: https://liabilis.com/order-colofac-online-en.html availability: in_stock shipping: - type: Standard Airmail price: 10.00 currency: USD area: Worldwide time: 14-21 days - type: Tracked Express price: 30.00 currency: USD area: Worldwide tracking: true time: 5-9 days price_min: 43.53 price_max: 348.61 currency: USD offers: - name: 135mg x 30 pills price: 43.53 - name: 135mg x 60 pills price: 63.97 - name: 135mg x 90 pills price: 97.52 - name: 135mg x 120 pills price: 118.97 - name: 135mg x 180 pills price: 173.26 - name: 135mg x 360 pills price: 348.61 --- # Buy Colofac (Mebeverin) 135mg Pills Online Colofac contains mebeverin hydrochloride and is an antispasmodic medication that relieves abdominal cramps, pain, and discomfort associated with irritable bowel syndrome. It works by relaxing the muscles in the gut wall, providing targeted relief for adults with IBS symptoms. Our pharmacy offers convenient access to Colofac in 135mg pills. ## Pricing and Options | Dosage | Pack Size | Price (USD) | Price Per Pill | Status | | :--- | :--- | :--- | :--- | :--- | | **135mg** | 30 pills | **$43.53** | $1.45 | In Stock | | **135mg** | 60 pills | **$63.97** | $1.06 | In Stock | | **135mg** | 90 pills | **$97.52** | $1.08 | In Stock | | **135mg** | 120 pills | **$118.97** | $0.99 | In Stock | | **135mg** | 180 pills | **$173.26** | $0.96 | In Stock | | **135mg** | 360 pills | **$348.61** | $0.97 | In Stock | [Buy Now](https://liabilis.com/order-colofac-online-en.html) ## 1. Introduction Colofac is a generic oral medication that contains the antispasmodic agent mebeverin hydrochloride (135 mg per tablet). It belongs to the class of smooth-muscle relaxants used primarily to relieve abdominal cramping associated with irritable-bowel syndrome (IBS). The pill form provides a convenient once-to-three-times-daily dosing schedule, and the medication is approved for adult patients with functional bowel disorders. Secondary uses include occasional relief of other gastrointestinal spasm conditions when prescribed by a clinician. ## 2. Quick Reference Facts **Active Ingredient** : Mebeverin hydrochloride **Form** : pill 135 mg **Primary Uses** : • Relief of IBS-related abdominal pain and cramps : • Management of functional gastrointestinal spasm ## 3. What is Colofac? Colofac is the generic version of medications containing the active compound mebeverin hydrochloride. It is the generic equivalent of brand-name products marketed under names such as Colofac and Duspatin. As a smooth-muscle relaxant, it works by reducing the tone of intestinal smooth muscle, thereby diminishing painful spasms. The formulation is supplied as a film-coated tablet that delivers 135 mg of mebeverin per dose. While the original brand formulations were developed by pharmaceutical companies in Europe, the generic version is produced by multiple licensed manufacturers that meet international quality standards. ## 4. How Colofac Works Mebeverin hydrochloride antagonizes calcium influx in gastrointestinal smooth-muscle cells, leading to decreased contractility. By inhibiting calcium-dependent muscle contraction, the drug lessens the intensity and frequency of intestinal spasms that cause IBS pain. The onset of symptom relief typically occurs within 30 minutes after ingestion, and the therapeutic effect persists for several hours, allowing dosing every 8 hours for most patients. Mebeverin is metabolized primarily by the liver via CYP3A4 pathways and is excreted in the urine, which accounts for its relatively short half-life of 2-3 hours. ## 5. Conditions Treated with Colofac - **Irritable-Bowel Syndrome (IBS) with predominant abdominal pain** The antispasmodic action relaxes intestinal smooth muscle, reducing cramping and improving bowel comfort. - **Functional gastrointestinal spasm** In conditions where irregular smooth-muscle contraction leads to discomfort, mebeverin dampens the spasm without affecting overall motility. - **Colonic diverticulosis-related cramping** (off-label, see Section 10) Some clinicians use the drug to alleviate spasm-related pain in diverticular disease, although this use is not formally approved. ## 6. Is Colofac the Right Medication for You? Colofac is suitable for adults diagnosed with IBS who experience recurrent abdominal cramps that are not fully controlled by diet or fiber supplementation. It is especially helpful when pain is linked to spasmodic activity rather than constipation or diarrhea alone. Patients should avoid the medication if they have a known hypersensitivity to mebeverin hydrochloride or any tablet excipients. Caution is advised in individuals with severe hepatic impairment, as metabolism may be reduced. Pregnant or breastfeeding women should consult their doctor before initiating therapy because safety data are limited. ## 7. Buying Colofac from [our online pharmacy](https://liabilis.com/order-colofac-online-en.html) ### Why Choose Our Service? [our online pharmacy](https://liabilis.com/order-colofac-online-en.html) provides a discreet, cost-effective way to obtain Colofac when local pharmacies have limited stock or when brand-name prices are prohibitive. ### Quality & Safety Assurance We partner with licensed international pharmacies to ensure quality and authenticity. Every batch is verified against regulatory standards before shipment. ### Pricing & Access Because Colofac is a generic formulation, it is offered at a fraction of the cost of brand-name equivalents. This makes long-term IBS management more affordable for patients who need regular therapy. ### Discreet Delivery Orders are packaged in unmarked envelopes and dispatched with express delivery typically within 7 days, or standard airmail in approximately 3 weeks. Your privacy is protected throughout the shipping process. ## 8. Use: Dosing, Missed Dose, Overdose - **Standard dosing**: One 135 mg tablet three times daily, taken with meals to minimize gastrointestinal irritation. - **Missed dose**: If a dose is forgotten, take it as soon as you remember unless it is close to the next scheduled dose; in that case, skip the missed tablet and resume the regular schedule. Do not double-dose. - **Overdose**: Symptoms may include excessive drowsiness, nausea, or vomiting. Seek immediate medical attention or contact a poison-control center. - **Administration tips**: Swallow the tablet whole with a full glass of water. Avoid alcohol while taking Colofac, as it may increase sedation. Do not operate machinery if you feel dizzy or unsteady. ## 9. Safety Information ### ⚠️ Who Should Not Take Colofac - Patients with a documented allergy to mebeverin hydrochloride or any tablet component. - Individuals with severe liver disease (Child-Pugh class C) because clearance is markedly reduced. - Children and adolescents under 18 years of age; safety has not been established. ### Common Side Effects - Mild headache (≤10 % of users) - usually transient. - Nausea or abdominal discomfort (5-8 %) - often resolves after the first few doses. - Drowsiness or fatigue (3-5 %) - advise caution when driving or using heavy machinery. ### Serious Side Effects (Seek Immediate Medical Help) - Severe allergic reactions: rash, itching, swelling of face or throat, difficulty breathing. - Hepatotoxicity signs: jaundice, dark urine, unusual fatigue. - Cardiac arrhythmias (very rare) - palpitations or syncope. ### Drug & Food Interactions - **CYP3A4 inhibitors** (e.g., ketoconazole, erythromycin): may increase plasma levels of mebeverin, heightening side-effect risk. - **Anticholinergic agents**: additive smooth-muscle relaxation could lead to excessive gastrointestinal hypomotility. - **Alcohol**: can potentiate central nervous system depression, especially drowsiness. - **Grapefruit juice**: modestly inhibits CYP3A4; limit intake to avoid higher drug exposure. ## 10. Off-Label and Investigational Uses of Colofac - **Diverticular disease-related pain** - Small case series suggest benefit, but robust clinical trials are lacking. - **Functional dyspepsia with spasm-dominant symptoms** - Preliminary studies indicate potential improvement in upper-abdominal discomfort. - **Post-operative intestinal spasm** - Occasionally used to reduce postoperative cramping, though evidence remains limited. Off-label use should only be considered under the direct supervision of a qualified healthcare provider, as efficacy and safety have not been formally approved by regulatory agencies. ## 11. Storage & Handling - Store tablets at 20-25 °C (68-77 °F) in a dry place, protected from excess heat and moisture. - Keep the container tightly closed and out of reach of children. - Do not use after the expiration date printed on the package. - Dispose of unused tablets according to local pharmaceutical waste guidelines or return to a pharmacy for safe disposal. ## 12. Frequently Asked Questions **Practical Use & Lifestyle** - **Can I travel internationally with Colofac?** Yes, the tablet form is stable at room temperature and can be carried in a personal medication bag. Keep the original packaging to facilitate customs inspection if required. - **Should I take Colofac with food?** Taking the tablet with meals reduces the likelihood of stomach irritation and improves tolerability. - **Is it safe to combine Colofac with probiotic supplements?** Probiotics act locally in the gut and do not affect the metabolism of mebeverin, so concurrent use is generally considered safe. **Product & Formulation Details** - **What does a Colofac tablet look like?** The tablet is typically white, film-coated, and film-marked with “135 mg”. Appearance may vary slightly by manufacturer. - **Are there any inactive ingredients I should be aware of?** Common excipients include lactose, microcrystalline cellulose, and magnesium stearate. Patients with lactose intolerance should verify the specific formulation. **Regulatory & Safety Nuances** - **Will Colofac appear on a drug test for athletes?** Mebeverin is not listed as a prohibited substance by major sports agencies, but athletes should review the most current regulations. - **Can seniors use Colofac safely?** Older adults may be more sensitive to drowsiness and should start at the lowest effective dose, monitoring for adverse effects. **Scientific & Clinical Curiosity** - **What clinical trial supported the approval of mebeverin for IBS?** Randomized, double-blind studies demonstrated a statistically significant reduction in abdominal pain scores compared with placebo over a 4-week period. - **How does mebeverin differ from other antispasmodics like hyoscine?** Mebeverin selectively targets intestinal smooth muscle without significant anticholinergic activity, resulting in fewer dry-mouth or blurred-vision side effects. ## 13. Glossary **Antispasmodic** : A medication that reduces involuntary smooth-muscle contractions, alleviating cramping. **CYP3A4** : An enzyme in the liver that metabolizes many drugs; inhibition can raise blood levels of the affected medication. **Bioequivalence** : Demonstrates that a generic product delivers the same amount of active ingredient to the bloodstream as the reference brand product. **Therapeutic Window** : The dosage range in which a drug is effective without causing unacceptable side effects. ## 14. Disclaimer The information provided about **Colofac** is for general knowledge only. It does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. [our online pharmacy](https://liabilis.com/order-colofac-online-en.html) offers access to **Colofac** for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.