--- title: Buy Generic Benemid 500mg Pills Online description: Generic Benemid (Probenecid) treats gout by reducing uric acid levels in the blood. Order from our secure pharmacy for trusted medication. type: product language: en url: https://liabilis.com/order-benemid-online-en.html availability: in_stock shipping: - type: Standard Airmail price: 10.00 currency: USD area: Worldwide time: 14-21 days - type: Tracked Express price: 30.00 currency: USD area: Worldwide tracking: true time: 5-9 days price_min: 57.99 price_max: 324.89 currency: USD offers: - name: 500mg x 30 pills price: 57.99 - name: 500mg x 60 pills price: 75.24 - name: 500mg x 90 pills price: 98.01 - name: 500mg x 120 pills price: 135.99 - name: 500mg x 180 pills price: 184.99 - name: 500mg x 360 pills price: 324.89 --- # Buy Generic Benemid 500mg Pills Online Generic Benemid contains probenecid, a medication that helps treat gout and gouty arthritis by helping the kidneys eliminate uric acid from the body. It is used to prevent gout attacks rather than treat acute attacks, making it suitable for long-term management of chronic gout. This medication is designed for adults with recurring gout symptoms. Our pharmacy provides reliable access to generic Benemid in 500mg pill form. ## Pricing and Options | Dosage | Pack Size | Price (USD) | Price Per Pill | Status | | :--- | :--- | :--- | :--- | :--- | | **500mg** | 30 pills | **$57.99** | $1.92 | In Stock | | **500mg** | 60 pills | **$75.24** | $1.25 | In Stock | | **500mg** | 90 pills | **$98.01** | $1.09 | In Stock | | **500mg** | 120 pills | **$135.99** | $1.13 | In Stock | | **500mg** | 180 pills | **$184.99** | $1.03 | In Stock | | **500mg** | 360 pills | **$324.89** | $0.90 | In Stock | [Buy Now](https://liabilis.com/order-benemid-online-en.html) ## 1. Introduction Benemid is a tablet formulation that contains the active ingredient **Probenecid**. It is supplied as a 500 mg pill and belongs to the class of uricosuric agents, which promote the excretion of uric acid in the urine. The primary indication for Benemid is the long-term management of chronic gout, where it helps to lower serum uric acid levels and reduce the frequency of gout flares. Secondary uses include enhancing the plasma concentrations of certain antibiotics (e.g., penicillins) by inhibiting renal tubular secretion. --- ## 2. Quick Reference Facts ``` **Active Ingredient** : Probenecid **Form** : pill 500 mg **Primary Uses** : • Chronic gout (uric acid-lowering) • Adjunct to selected β-lactam antibiotics ``` --- ## 3. What is Benemid? Benemid is the generic version of medications containing the active compound **Probenecid**. Probenecid is marketed under brand names such as **Benemid**, **Prouric**, and **Uristat**. As a generic product, Benemid is chemically identical to the branded formulations and meets the same regulatory standards for safety, efficacy, and quality. It is manufactured for oral administration in a solid tablet form, each containing 500 mg of Probenecid. The drug was originally developed in the 195s to treat gout by increasing renal clearance of uric acid. Over the decades, its pharmacological profile has been refined, and generic manufacturers now produce cost-effective equivalents that are widely available internationally. --- ## 4. How Benemid Works Probenecid acts on the proximal tubules of the kidneys, where it blocks the reabsorption transporter **URAT1** (uric acid transporter 1). By inhibiting URAT1, the drug reduces the reclamation of uric acid from the filtrate back into the bloodstream, resulting in increased urinary excretion of uric acid. The enhanced clearance lowers serum uric acid concentrations, which in turn diminishes crystal deposition in joints and soft tissues-a central factor in gout pathogenesis. In addition to its uricosuric effect, Probenecid interferes with the organic anion transporters (OAT1 and OAT3) responsible for the renal secretion of many β-lactam antibiotics. This interaction slows the renal elimination of such antibiotics, leading to higher plasma levels and prolonged therapeutic exposure. The dual mechanisms make Probenecid useful both as a gout therapy and as a pharmacokinetic booster for selected antimicrobial regimens. Probenecid is absorbed rapidly from the gastrointestinal tract, reaching peak plasma concentrations within 1-2 hours. It is minimally metabolized and is excreted unchanged in the urine, with a plasma half-life of roughly 4-12 hours, depending on renal function. --- ## 5. Conditions Treated with Benemid - **Chronic gout** - By lowering serum urate, Benemid reduces the formation of monosodium urate crystals that trigger painful joint inflammation. Long-term use helps maintain uric acid levels below the supersaturation threshold (≈ 6 mg/dL). - **Adjunctive therapy for β-lactam antibiotics** - When used alongside penicillins (e.g., ampicillin, amoxicillin) or cephalosporins, Benemid prolongs antibiotic exposure, allowing lower or less frequent dosing while preserving efficacy-particularly useful in difficult-to-treat infections such as meningitis or osteomyelitis. These indications are reflected in the regulatory approvals of Probenecid in the United States, Europe, and many other jurisdictions. --- ## 6. Is Benemid the Right Medication for You? Benemid is most appropriate for adults who: - Have a confirmed diagnosis of gout with persistent hyperuricemia despite lifestyle measures. - Require a uricosuric approach because xanthine oxidase inhibitors (e.g., allopurinol, febuxostat) are contraindicated, poorly tolerated, or insufficient alone. - Possess normal to mildly reduced renal function (eGFR ≥ 30 mL/min/1.73 m²), since the drug’s efficacy depends on kidney filtration. Contraindications include: - Severe renal impairment (eGFR < 30 mL/min/1.73 m²). - Known hypersensitivity to Probenecid or any tablet excipients. - Active urinary tract obstruction or kidney stones composed of uric acid, which may worsen obstruction due to increased uric acid excretion. Patients with a history of sulfonamide allergy should exercise caution, as cross-reactivity, though rare, has been reported. Clinicians typically assess renal function, baseline uric acid levels, and potential drug interactions before initiating therapy. --- ## 7. Buying Benemid from [our online pharmacy](https://liabilis.com/order-benemid-online-en.html) ### Why Choose Our Service? Accessing Benemid can be challenging in regions where the brand is no longer stocked or where insurance coverage imposes high co-payments. Our platform offers a reliable avenue to obtain the generic alternative at a price close to the manufacturer’s wholesale cost, helping you maintain your treatment without financial strain. ### Quality & Safety Assurance We partner with licensed international pharmacies to ensure quality and authenticity. All suppliers operate under recognized regulatory frameworks and are subject to routine audits, guaranteeing that every bottle of Benemid meets the same standards as locally approved medicines. ### Pricing & Access The generic formulation of Probenecid is significantly less expensive than branded equivalents such as Benemid or Prouric, often reducing out-of-pocket costs by 40 % or more. Our service also sources Benemid for patients residing in countries where the medication is not commercially available, providing a practical solution for continued gout management. ### Discreet Delivery Your order arrives in unmarked packaging, protecting your privacy. Standard shipping typically delivers within 7 days, while express options are available for faster receipt. All shipments are tracked and handled with secure, tamper-evident containers. --- ## 8. Use: Dosing, Missed Dose, Overdose **Standard dosing for chronic gout** - Adults: 500 mg tablet taken orally every 8 hours (three times daily). - Dose may be adjusted to 500 mg twice daily if renal function is borderline or if side effects occur. **Adjunctive antibiotic use** - A single 500 mg dose of Benemid is administered concurrently with the first dose of a β-lactam antibiotic; no further Benemid dosing is required for the antibiotic course. **Missed dose** - If you miss a dose and it is within 4 hours of the scheduled time, take it as soon as you remember. - If more than 4 hours have passed, skip the missed dose and resume your regular schedule. Do not double-dose to compensate. **Overdose** - Symptoms may include nausea, vomiting, abdominal pain, and a marked increase in urinary output. - Seek immediate medical attention or contact a poison control center. Treatment focuses on supportive care and monitoring renal function. **Practical precautions** - Take Benemid with a full glass of water; food does not significantly affect absorption. - Avoid concurrent use of high-dose aspirin (≥ 325 mg) as it may diminish the uricosuric effect. - Refrain from operating heavy machinery if you experience dizziness or visual disturbances. --- ## 9. Safety Information ### ⚠️ Who Should Not Take Benemid - Patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²). - Individuals with known hypersensitivity to Probenecid, sulfonamides, or any tablet excipients. - Those with active uric acid kidney stones or urinary tract obstruction. ### Common Side Effects - **Gastrointestinal:** mild nausea, abdominal discomfort, or dyspepsia (usually transient). - **Renal:** increased urinary frequency and volume due to enhanced uric acid excretion. - **Dermatologic:** occasional rash or pruritus; generally resolves without discontinuation. ### Serious Side Effects (Seek Immediate Medical Help) - **Severe allergic reactions:** swelling of the face, lips, tongue, or throat, difficulty breathing, or widespread hives. - **Acute kidney injury:** sudden decrease in urine output, flank pain, or elevated serum creatinine. - **Hemolytic anemia** in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, presenting as dark urine, fatigue, or jaundice. ### Drug & Food Interactions - **Aspirin (high dose):** may reduce the uricosuric effect of Benemid. - **Sulfonamide antibiotics:** concurrent use can increase the risk of hypersensitivity reactions. - **Methotrexate:** Probenecid may raise methotrexate plasma concentrations, requiring dose adjustment. - **Warfarin:** occasional reports of altered INR; monitor coagulation parameters when initiating or discontinuing Benemid. - **Alcohol:** heavy consumption can exacerbate gout flares and should be limited. --- ## 10. Off-Label and Investigational Uses of Benemid - **Management of hyperuricemia in tumor lysis syndrome:** Small case series suggest Probenecid may aid in rapid uric acid reduction when combined with other agents, though it is not FDA-approved for this indication. - **Adjunct in certain antiviral regimens:** Early laboratory studies indicate that Probenecid can increase intracellular concentrations of some nucleoside analogues, but clinical data remain limited. - **Potential role in chronic kidney disease (CKD) progression:** Observational research has explored whether lowering uric acid with benemid slows CKD progression; results are inconclusive and require larger trials. Off-label use should only be considered under the direct supervision of a qualified healthcare provider, as safety and efficacy have not been formally established for these applications. --- ## 11. Storage & Handling - Store tablets at a controlled room temperature of 20 °C to 25 °C (68 °F to 77 °F). - Protect from excess heat, moisture, and direct sunlight. - Keep the container tightly closed to maintain stability. - Do not use the medication after the expiration date printed on the label. - Dispose of unused tablets according to local pharmaceutical waste regulations-do not flush them down the toilet. --- ## 12. Frequently Asked Questions **Practical Use & Lifestyle** - **Can I travel internationally with Benemid?** Yes, but carry the medication in its original labeling and a copy of the prescription if required by customs. Keep it in your carry-on luggage to avoid temperature extremes. - **Will drinking lots of water affect Benemid’s effectiveness?** Adequate hydration supports uric acid excretion and helps prevent kidney stone formation. Maintaining normal fluid intake is recommended, but excessive water does not diminish the drug’s action. - **Is it safe to take Benemid before a marathon?** If you have stable gout and no renal issues, Benemid can be continued. Monitor for dehydration, as prolonged exercise may increase urinary concentration of uric acid. **Product & Formulation Details** - **What do Benemid tablets look like?** The generic 500 mg tablets are typically round, white to off-white, and may bear a faint imprint of the manufacturer’s code. Appearance can vary among licensed suppliers. - **Are there any inactive ingredients I should avoid?** Common excipients include lactose, microcrystalline cellulose, and magnesium stearate. Patients with lactose intolerance or specific excipient allergies should review the full ingredient list provided by the pharmacy. **Regulatory & Safety Nuances** - **Will Benemid appear on a standard drug test?** Probenecid is not a controlled substance and is not screened for in routine employment drug panels. - **Can athletes use Benemid without violating anti-doping rules?** Probenecid is listed on the World Anti-Doping Agency (WADA) prohibited list when used in competition. Athletes must obtain a Therapeutic Use Exemption (TUE) if prescribed for a legitimate medical condition. - **Is Benemid safe during pregnancy?** Animal studies have not shown teratogenic effects, but human data are limited. The drug is classified as Category C, meaning it should only be used if the potential benefit justifies the potential risk to the fetus. - **How does renal impairment alter Benemid dosing?** Reduced kidney function decreases drug clearance, increasing plasma concentrations. Dose reductions or extended dosing intervals are typically recommended for eGFR 30-50 mL/min/1.73 m². **Scientific & Clinical Curiosity** - **What was the original purpose of Probenecid’s development?** It was first synthesized to increase the urinary excretion of penicillins, thereby extending their therapeutic levels. Its uricosuric properties were discovered subsequently, leading to its use in gout. - **How does Benemid compare to allopurinol in efficacy?** Allopurinol reduces uric acid production, while Benemid enhances elimination. In patients who cannot tolerate allopurinol, Benemid provides a comparable reduction in serum urate when appropriately, though individual response varies. --- ## 13. Glossary **Uricosuric agent** : A medication that promotes the excretion of uric acid in the urine, thereby lowering blood urate levels. **URAT1 (Uric Acid Transporter 1)** : A protein in the renal proximal tubule responsible for reabsorbing uric acid from the filtrate back into the bloodstream; inhibition leads to increased uric acid clearance. **Bioequivalence** : The property whereby two drug products (e.g., a generic and its brand-name counterpart) release the same amount of active ingredient into the bloodstream at the same rate and extent. **eGFR (estimated Glomerular Filtration Rate)** : A calculated measure of kidney function based on serum creatinine, age, sex, and body size; used to adjust dosing of renally cleared drugs. **Therapeutic Use Exemption (TUE)** : An authorization allowing an athlete to use a prohibited substance for a legitimate medical condition under strict anti-doping regulations. --- ## 14. Disclaimer The information provided about **Benemid** is intended for general educational purposes and does not substitute for professional medical consultation. All therapeutic decisions, including those concerning off-label applications, should be made under the guidance of a qualified healthcare provider. Readers are presumed to be competent adults capable of making informed health choices. [our online pharmacy](https://liabilis.com/order-benemid-online-en.html) supplies Benemid to individuals who may encounter limited availability through conventional channels or who seek cost-effective generic alternatives. Prior to initiating, modifying, or stopping any medication, it is essential to discuss the plan with your doctor.