--- title: Buy Asacol Mesalamine 400mg Pills Online description: Asacol (Mesalamine) 400mg Pills is a trusted treatment for ulcerative colitis and maintaining remission. Order from our secure online pharmacy. type: product language: en url: https://liabilis.com/order-asacol-online-en.html availability: in_stock shipping: - type: Standard Airmail price: 10.00 currency: USD area: Worldwide time: 14-21 days - type: Tracked Express price: 30.00 currency: USD area: Worldwide tracking: true time: 5-9 days price_min: 52.99 price_max: 228.99 currency: USD offers: - name: 400mg x 30 pills price: 52.99 - name: 400mg x 60 pills price: 89.76 - name: 400mg x 90 pills price: 126.72 - name: 400mg x 120 pills price: 162.99 - name: 400mg x 180 pills price: 228.99 --- # Buy Asacol Mesalamine 400mg Pills Online Asacol contains Mesalamine, an anti-inflammatory medication specifically developed for gastrointestinal conditions. It works directly in the colon to reduce inflammation and is used to treat mild to moderate ulcerative colitis and maintain remission. This medication is designed for adults managing inflammatory bowel disease who need targeted colon therapy. Our pharmacy provides reliable access to Asacol in 400mg pills with discreet shipping. ## Pricing and Options | Dosage | Pack Size | Price (USD) | Price Per Pill | Status | | :--- | :--- | :--- | :--- | :--- | | **400mg** | 30 pills | **$52.99** | $1.75 | In Stock | | **400mg** | 60 pills | **$89.76** | $1.50 | In Stock | | **400mg** | 90 pills | **$126.72** | $1.41 | In Stock | | **400mg** | 120 pills | **$162.99** | $1.36 | In Stock | | **400mg** | 180 pills | **$228.99** | $1.27 | In Stock | [Buy Now](https://liabilis.com/order-asacol-online-en.html) ## 1. Introduction Asacol is an oral medication that contains the anti-inflammatory agent mesalamine. It is supplied as a 400 mg tablet and belongs to the class of 5-aminosalicylic acid (5-ASA) drugs. Asacol is primarily used to induce and maintain remission in ulcerative colitis, a chronic inflammatory condition of the colon. The formulation is also indicated for maintenance therapy in Crohn’s disease involving the colon, although this indication is less common. ## 2. Quick Reference Facts **Active Ingredient** : Mesalamine **Form** : Pill - 400 mg **Primary Uses** : Induction and maintenance of remission in ulcerative colitis; maintenance therapy for colonic Crohn’s disease ## 3. What is Asacol? Asacol is the generic version of medications containing the active compound mesalamine. It is marketed under brand names such as Asacol, Salofalk, and Lialda. The product is manufactured by several licensed pharmaceutical companies that submit the same active ingredient, dosage strength, and release profile to regulatory agencies for approval. As a generic mesalamine formulation, Asacol is bioequivalent to the branded counterparts, offering the same therapeutic effect at a lower cost. ## 4. How Asacol Works Mesalamine belongs to the 5-ASA family, which exerts its effect directly on the lining of the gastrointestinal tract. After oral ingestion, the tablet is coated to resist stomach acidity and releases mesalamine primarily in the distal small intestine and colon. Mesalamine inhibits cyclooxygenase and lipoxygenase pathways, reducing the production of prostaglandins and leukotrienes-key mediators of inflammation. It also modulates nuclear factor-κB (NF-κB) signaling, limiting cytokine release from intestinal immune cells. By targeting these inflammatory cascades locally, mesalamine lowers mucosal inflammation without significant systemic absorption, leading to symptom relief and mucosal healing. The onset of action typically occurs within 7-14 days of consistent dosing, and therapeutic levels are maintained with regular twice-daily administration due to its relatively short plasma half-life. ## 5. Conditions Treated with Asacol - **Ulcerative colitis (induction of remission)** Mesalamine reduces colonic inflammation, helping patients achieve symptom-free periods and endoscopic healing. - **Ulcerative colitis (maintenance of remission)** Continued therapy sustains mucosal integrity, decreasing the likelihood of flare-ups. - **Crohn’s disease involving the colon (maintenance)** For patients with colonic involvement, mesalamine helps prevent relapse after surgical or medical induction of remission. Each indication is supported by randomized controlled trials demonstrating that mesalamine therapy improves clinical scores, endoscopic appearance, and quality-of-life metrics compared with placebo. ## 6. Is Asacol the Right Medication for You? Asacol is appropriate for adults with mild to moderate ulcerative colitis who require either induction or maintenance therapy. It is also suitable for those with colonic Crohn’s disease who have responded to prior mesalamine therapy. The medication is particularly beneficial for patients who prefer a non-systemic treatment and who tolerate oral tablets well. Contraindications include known hypersensitivity to mesalamine or other 5-ASA compounds, severe renal impairment (creatinine clearance < 30 mL/min), and a history of hypersensitivity pneumonitis related to mesalamine. Caution is advised in patients with liver disease, congestive heart failure, or a history of pancreatitis, as systemic absorption may be increased. Patients with active severe ulcerative colitis or extensive colonic disease may require faster-acting agents such as corticosteroids or biologics and should discuss alternative strategies with their clinician. ## 7. Buying Asacol from [our online pharmacy](https://liabilis.com/order-asacol-online-en.html) **Why Choose Our Service?** Accessing mesalamine can be challenging due to insurance restrictions or limited local stock. [our online pharmacy](https://liabilis.com/order-asacol-online-en.html) provides a reliable channel to obtain Asacol at a price close to the manufacturer’s cost, eliminating mark-ups common in brick-and-mortar pharmacies. **Quality & Safety Assurance** We partner with licensed international pharmacies to ensure quality and authenticity. Every batch of Asacol is sourced from certified distributors who comply with Good Manufacturing Practices and are regularly inspected by regulatory authorities. **Pricing & Access** Because Asacol is a generic formulation of mesalamine, it is offered at a fraction of the price of branded alternatives such as Salofalk or Lialda. Our pharmacy service enables patients worldwide to purchase Asacol even when local formularies do not list it. **Discreet Delivery** Orders are packaged in plain, unmarked envelopes and shipped via express courier with typical delivery within 7 days, or by standard airmail in approximately 3 weeks. Your privacy is protected throughout the process, from ordering to receipt. ## 8. Use: Dosing, Missed Dose, Overdose - **Standard dosing**: The usual adult dose for ulcerative colitis induction is 800 mg twice daily (total 160 mg/day). For maintenance, 800 mg once or twice daily is common, depending on disease severity and physician judgment. - **Missed dose**: If a dose is missed and it is less than 12 hours until the next scheduled dose, skip the missed tablet and resume the regular schedule. Do not double-dose to compensate. - **Overdose**: In the event of an overdose, contact emergency services or a poison control center immediately. Symptoms may include nausea, vomiting, abdominal cramps, and, rarely, renal dysfunction. Prompt medical evaluation is essential. - **Administration advice**: Tablets should be swallowed whole with water; crushing or splitting may disrupt the delayed-release coating. Avoid taking Asacol with antacids containing aluminum or magnesium within 2 hours, as they may interfere with drug release. Alcohol does not directly affect efficacy but may exacerbate gastrointestinal irritation. Patients should refrain from operating heavy machinery until they know how Asacol affects them, especially during the initial treatment phase. ## 9. Safety Information ### ⚠️ Who Should Not Take Asacol - Known hypersensitivity to mesalamine or any 5-ASA component. - Severe renal impairment (creatinine clearance < 30 mL/min). - Active severe ulcerative colitis requiring immediate corticosteroid or biologic therapy. ### Common Side Effects - **Headache** (≈ 10 %): Usually mild; persisting headaches should be discussed with a clinician. - **Nausea or abdominal discomfort** (≈ 5-8 %): May lessen with continued use; taking tablets with food can help. - **Flatulence** (≈ 5 %): Typically transient. ### Serious Side Effects (Seek Immediate Medical Help) - **Acute pancreatitis**: Severe abdominal pain radiating to the back, elevated lipase/amylase. - **Renal dysfunction**: Rising serum creatinine, decreased urine output. - **Hypersensitivity pneumonitis**: Fever, cough, shortness of breath, diffuse lung infiltrates on imaging. ### Drug & Food Interactions - **Antacids containing aluminum or magnesium** - may delay mesalamine release; separate dosing by at least 2 hours. - **Sulfasalazine** - concurrent use can increase risk of renal toxicity; monitor renal function closely. - **Warfarin** - mesalamine may enhance anticoagulant effect; INR should be monitored more frequently. - **Live vaccines** - immunosuppressive therapy for IBD may diminish vaccine efficacy; discuss timing with your provider. ## 10. Off-Label and Investigational Uses of Asacol Some clinicians use mesalamine in the management of microscopic colitis and pouchitis after ileal-pouch-anal anastomosis, citing small-scale studies that suggest symptom improvement. Additionally, low-dose mesalamine has been investigated for chemoprevention of colorectal cancer in long-standing ulcerative colitis, although definitive evidence is lacking. Off-label use should only be considered under the direct supervision of a qualified healthcare provider, as safety and efficacy have not been formally approved by regulatory agencies. ## 11. Storage & Handling - Store tablets at room temperature (15 °C-30 °C/59 °F-86 °F) in a dry place away from moisture and direct sunlight. - Keep the container tightly closed to protect the delayed-release coating. - Do not use tablets beyond the printed expiry date; dispose of any remaining medication according to local pharmacy guidelines or by returning to a medication take-back program. ## 12. Frequently Asked Questions **Practical Use & Lifestyle** - **Can I travel internationally with Asacol tablets?** Yes. Keep the medication in its original container with a copy of the prescription or a letter from your provider. Ensure it is stored in your carry-on bag to avoid temperature extremes. - **Will taking Asacol interfere with my daily vitamin D supplement?** No known direct interaction exists. However, both are absorbed in the gut; spacing them by at least 2 hours may reduce any theoretical absorption competition. **Product & Formulation Details** - **What does an Asacol tablet look like?** The 400 mg tablet is round, white, and bears a debossed imprint of the dosage strength and manufacturer’s logo. Appearance may vary slightly between licensed manufacturers. - **Is it possible to split an Asacol tablet?** No. The tablet has a delayed-release coating designed to dissolve in the colon. Splitting compromises this mechanism and can lead to reduced efficacy or increased side effects. **Regulatory & Safety Nuances** - **Can Asacol show up on a sports drug test?** Mesalamine is not a prohibited substance under major anti-doping regulations. Routine drug testing panels do not screen for 5-ASA compounds. - **Do I need to declare Asacol when importing it for personal use?** Personal import limits vary by country. In many jurisdictions, a supply of up to a 90-day’s worth for personal use is permissible with a valid prescription. Check local customs regulations before ordering. **Scientific & Clinical Curiosity** - **How was mesalamine originally developed?** Mesalamine was derived from sulfasalazine in the 197s, with the sulfa moiety removed to reduce side-effects while retaining anti-inflammatory activity. - **Are there head-to-head trials comparing Asacol to other mesalamine brands?** Several bioequivalence studies have demonstrated that Asacol and other 5-ASA products (e.g., Salofalk, Lialda) achieve comparable colonic concentrations and clinical outcomes when dosed appropriately. ## 13. Glossary **5-ASA (5-Aminosalicylic Acid)** : A class of anti-inflammatory drugs that act locally in the intestinal mucosa to reduce inflammation. **Bioequivalence** : Demonstration that two drug products release the same amount of active ingredient into the bloodstream at the same rate under similar conditions. **Delayed-Release Coating** : A tablet coating that resists dissolution in the stomach, allowing the drug to be released further along the gastrointestinal tract, typically in the colon. **Renal Clearance** : The volume of plasma from which a substance is completely removed by the kidneys per unit time, often expressed in mL/min. ## 14. Disclaimer The information provided about **Asacol** is for general knowledge only. It does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. [our online pharmacy](https://liabilis.com/order-asacol-online-en.html) offers access to **Asacol** for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.