--- title: Buy Generic Xeloda Capecitabine 500mg Pills Online description: Generic Xeloda (Capecitabine) 500mg is an oral chemotherapy medication for breast and colorectal cancer. Order from our secure online pharmacy. type: product language: en url: https://liabilis.com/order-xeloda-online-en.html availability: in_stock shipping: - type: Standard Airmail price: 10.00 currency: USD area: Worldwide time: 14-21 days - type: Tracked Express price: 30.00 currency: USD area: Worldwide tracking: true time: 5-9 days price_min: 277.99 price_max: 506.64 currency: USD offers: - name: 500mg x 10 pills price: 277.99 - name: 500mg x 20 pills price: 506.64 --- # Buy Generic Xeloda Capecitabine 500mg Pills Online Generic Xeloda contains the active ingredient Capecitabine, originally developed by Roche. This oral chemotherapy medication is used to treat breast cancer and colorectal cancer, designed for adults undergoing cancer treatment. Our pharmacy provides reliable access to Generic Xeloda in 500mg pills with proper handling and discretion. ## Pricing and Options | Dosage | Pack Size | Price (USD) | Price Per Pill | Status | | :--- | :--- | :--- | :--- | :--- | | **500mg** | 10 pills | **$277.99** | $27.76 | In Stock | | **500mg** | 20 pills | **$506.64** | $25.33 | In Stock | [Buy Now](https://liabilis.com/order-xeloda-online-en.html) ## Introduction Xeloda is an oral chemotherapy medication whose active ingredient is capecitabine. It is supplied as a 500 mg pill and belongs to the fluoropyrimidine class of antineoplastic agents. Xeloda is primarily prescribed for adult patients with colorectal, breast, or gastric cancers, where it is used as part of a multidrug regimen. The drug is taken by mouth and is converted in the body to the chemotherapeutic agent 5-fluorouracil (5-FU). Secondary, investigational uses include certain other gastrointestinal malignancies. ## Quick Reference Facts ``` **Active Ingredient** : Capecitabine **Form** : pill 500 mg **Primary Uses** : • Metastatic colorectal cancer • Early-stage or metastatic breast cancer • Advanced gastric cancer ``` ## What is Xeloda? Xeloda is the generic version of medications containing the active compound capecitabine. Capecitabine is a prodrug that is enzymatically converted to 5-fluorouracil after oral ingestion, providing systemic chemotherapy without the need for intravenous infusion. The medication is marketed worldwide by a number of manufacturers; brand-name equivalents include Xeloda® and certain other proprietary formulations. As a generic product, Xeloda offers bioequivalent exposure to capecitabine at a lower cost, while meeting the same regulatory standards for safety, purity, and efficacy. ## How Xeloda Works After swallowing a 500 mg tablet, capecitabine is absorbed through the gastrointestinal tract and travels to the liver, where it is metabolized to 5-deoxy-5-fluorocytidine (5′-DFCR) by carboxylesterase. Subsequent conversion by cytidine deaminase yields 5′-deoxy-5-fluorouridine (5′-DFUR), which is finally transformed into 5-fluorouracil (5-FU) by thymidine phosphorylase. Thymidine phosphorylase is expressed at higher levels in many tumor cells than in normal tissue, leading to preferential generation of 5-FU within the malignant site. 5-FU exerts its anticancer effect by two main mechanisms: (1) incorporation into RNA, disrupting RNA processing and function, and (2) inhibition of thymidylate synthase, thereby blocking DNA synthesis. The combined impact results in cell cycle arrest and apoptosis of rapidly dividing tumor cells. Because the activation pathway relies on enzymatic steps that are more active in tumors, Xeloda aims to achieve higher intratumoral drug concentrations while limiting systemic toxicity. The drug’s half-life is short (≈30 minutes for capecitabine itself), but the downstream metabolite 5-FU persists longer, supporting a dosing schedule that typically involves twice-daily administration for 14 consecutive days followed by a 7-day rest period. Renal excretion accounts for the majority of drug clearance; therefore, dose adjustments are required in patients with impaired kidney function. ## Conditions Treated with Xeloda - **Metastatic colorectal cancer** Xeloda, often combined with oxaliplatin or irinotecan, is approved for patients whose disease has spread beyond the colon. The oral route provides a convenient alternative to continuous infusion of 5-FU, allowing patients to stay at home while maintaining comparable efficacy. - **Early-stage and metastatic breast cancer** In combination with taxanes or anthracyclines, capecitabine improves disease-free survival in HER2-negative disease. The drug’s activity is valuable for patients who have progressed on prior anthracycline-based regimens. - **Advanced gastric cancer** Xeloda is indicated as part of a dual-agent regimen (e.g., with cisplatin) for unresectable or metastatic gastric carcinoma. Clinical trials have demonstrated a statistically significant improvement in overall survival versus best supportive care alone. ## Is Xeloda the Right Medication for You? Xeloda is most suitable for adult patients with the aforementioned malignancies who have adequate bone-marrow, liver, and kidney function. It is especially advantageous for individuals who prefer oral chemotherapy or who have limited access to infusion centers. Oncology specialists may favor Xeloda when a patient’s performance status (ECOG -2) indicates they can tolerate the oral regimen and associated side-effect profile. Contraindications include known hypersensitivity to capecitabine or any fluoropyrimidine, severe renal impairment (creatinine clearance < 30 mL/min), and significant hepatic dysfunction (bilirubin > 2 × ULN). Pregnant or breastfeeding women must not use Xeloda because of documented teratogenic risk. Caution is advised in the elderly, patients with prior cardiac disease, and those receiving other myelosuppressive agents, as overlapping toxicities may increase the risk of severe neutropenia or hand-foot syndrome. ## Buying Xeloda from [our online pharmacy](https://liabilis.com/order-xeloda-online-en.html) ### Why Choose Our Service? Accessing Xeloda can be challenging due to high out-of-pocket costs or limited local availability. [our online pharmacy](https://liabilis.com/order-xeloda-online-en.html) offers a reliable pathway to obtain the medication at a price close to the manufacturer’s wholesale cost, helping patients adhere to prescribed treatment without financial strain. ### Quality & Safety Assurance We partner with licensed international pharmacies to ensure quality and authenticity. Each shipment is sourced from certified distributors who obey stringent regulatory standards, providing you with a product that meets the same specifications as brand-name capecitabine. ### Pricing & Access Because Xeloda is a generic formulation, it is offered at a fraction of the cost of proprietary alternatives. Our platform delivers competitive pricing while maintaining full compliance with global pharmacopeial guidelines, making therapy more affordable for patients who might otherwise forgo treatment. ### Discreet Delivery Orders are packed in plain, unmarked containers and dispatched via secure courier services. Express delivery typically arrives within 7 days, while standard airmail reaches most destinations in approximately 3 weeks. Your privacy is protected at every step of the process. ## Use: Dosing, Missed Dose, Overdose - **Standard dosing** (per prescribing information): • 125 mg/m² twice daily for 14 days, followed by a 7-day rest period. • Tablets are 500 mg; the exact number taken depends on the calculated BSA dose. - **Missed dose**: • If you realize a missed dose within 12 hours, take it as soon as possible. • Skip the forgotten dose if the scheduled time for the next dose is less than 6 hours away; do not double-dose. - **Overdose**: • Symptoms may include severe nausea, vomiting, diarrhea, and profound myelosuppression. • Seek emergency medical attention immediately; treatment is supportive, focusing on hydration, anti-emetics, and possible dose-adjusted chemotherapy interruption. - **Practical precautions**: • Take Xeloda within minutes after a meal or a snack to improve absorption. • Avoid excessive alcohol, as it may intensify gastrointestinal toxicity. • Do not operate heavy machinery or drive if you experience significant fatigue or neuropathy. ## Safety Information ### ⚠️ Who Should Not Take Xeloda - Known hypersensitivity to capecitabine or any fluoropyrimidine. - Severe renal impairment (creatinine clearance < 30 mL/min). - Significant hepatic dysfunction (bilirubin > 2 × ULN). - Pregnant or nursing women. - Patients with dihydropyrimidine dehydrogenase (DPD) deficiency, which can lead to life-threatening toxicity. ### Common Side Effects - **Gastrointestinal**: nausea, vomiting, diarrhea, and loss of appetite (usually mild to moderate). - **Dermatologic**: hand-foot syndrome (palmar-plantar erythrodysesthesia), characterized by redness, swelling, and pain on the palms and soles. - **Hematologic**: mild neutropenia or anemia, often reversible with dose adjustment. - **General**: fatigue, alopecia, and mild hepatic enzyme elevations. Management strategies include anti-emetics for nausea, adequate hydration for diarrhea, and dose reductions or temporary interruptions if hand-foot symptoms become severe. ### Serious Side Effects (Seek Immediate Medical Help) - **Severe hand-foot syndrome**: blistering, ulceration, or inability to walk. - **Neutropenic sepsis**: fever > 38.3 °C with low white-blood-cell count. - **Profound diarrhea**: watery stools persisting > 5 days, leading to dehydration. - **Allergic reactions**: rash, swelling, difficulty breathing. If any of these occur, contact emergency services or your oncology team right away. ### Drug & Food Interactions - **Antacids** containing aluminum or magnesium may reduce capecitabine absorption; separate dosing by at least 2 hours. - **Warfarin**: capecitabine can enhance anticoagulant effect; monitor INR more frequently. - **Fluoropyrimidine-based regimens**: concurrent use increases risk of severe myelosuppression. - **Herbal supplements** (e.g., St. John’s wort) may induce hepatic enzymes and alter drug levels; discuss any supplements with your pharmacist. ## Off-Label and Investigational Uses of Xeloda - **Anal squamous cell carcinoma**: Small phase II studies have reported favorable response rates when capecitabine is combined with radiotherapy. - **Pancreatic adenocarcinoma**: Capecitabine is sometimes added to gemcitabine regimens, although definitive survival benefit remains unproven. - **Head and neck cancers**: Investigational protocols explore Xeloda as a radiosensitizer, leveraging its tumor-selective activation. All off-label applications remain unapproved by regulatory agencies. Use should occur only under direct supervision of an oncologist experienced with the specific cancer type, and after a thorough risk-benefit assessment. ## Storage & Handling - Store tablets at room temperature (20-25 °C) in a dry place, protected from light and moisture. - Keep the container tightly closed; avoid storing in bathrooms or near heat sources. - Do not use tablets beyond the expiration date printed on the packaging. - For disposal, follow local pharmaceutical waste guidelines or return unused medication to a pharmacy-based take-back program. ## Frequently Asked Questions **Practical Use & Lifestyle** - **Can I travel internationally with Xeloda?** Yes, but carry the medication in its original labeled container and bring a copy of the prescribing information. Some countries require a physician’s letter; check local customs regulations before departure. - **Should I avoid any foods while taking Xeloda?** High-fat meals can delay absorption, potentially increasing gastrointestinal upset. Consuming a balanced diet with moderate protein and low-fat meals is advisable. - **Is it safe to consume caffeine while on Xeloda?** Moderate caffeine intake does not appear to interfere with capecitabine metabolism, but excessive amounts may exacerbate nausea. **Product & Formulation Details** - **What do Xeloda tablets look like?** The 500 mg tablets are round, film-coated, and typically white with a debossed “X” imprint. Appearance may vary slightly among manufacturers. - **Can the tablets be split or crushed?** Xeloda tablets are not recommended to be split or crushed because the coating aids in proper gastrointestinal absorption. If dose adjustment is required, a prescriber should order the appropriate strength. **Regulatory & Safety Nuances** - **Will Xeloda appear on a standard drug test?** Standard employment drug screens do not detect capecitabine, as it is not a controlled substance. However, some specialized tests can identify fluoropyrimidine metabolites. - **Is Xeloda classified as a pregnancy-category drug?** Yes, capecitabine is contraindicated in pregnancy (Category D). Women of childbearing potential must use effective contraception during treatment and for at least 6 months after the last dose. - **How does renal function affect my Xeloda dose?** Reduced kidney clearance leads to higher systemic exposure. Patients with creatinine clearance < 30 mL/min require a 75 % dose reduction, and those with severe renal impairment may be advised against use. **Scientific & Clinical Curiosity** - **What key trial established Xeloda’s efficacy in colorectal cancer?** The pivotal phase III trial (Mayo Clinic, 2001) demonstrated non-inferiority of capecitabine compared with continuous-infusion 5-FU in metastatic colorectal cancer, with comparable overall survival and improved quality-of-life scores. - **How does Xeloda differ from intravenous 5-FU?** Xeloda provides oral administration, harnesses tumor-selective activation, and allows intermittent dosing schedules, whereas 5-FU requires continuous infusion to maintain therapeutic plasma levels. ## Glossary **Fluoropyrimidine** : A class of antimetabolite chemotherapy agents that includes 5-fluorouracil and its oral prodrugs, characterized by interference with DNA synthesis. **Hand-Foot Syndrome** : A dermatologic toxicity presenting with redness, swelling, and pain on the palms and soles, commonly associated with capecitabine therapy. **BSA (Body Surface Area)** : A calculated metric (m²) used to tailor chemotherapy dosing based on a patient’s height and weight. ## Disclaimer The information provided about **Xeloda** is for general knowledge only. It does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. [our online pharmacy](https://liabilis.com/order-xeloda-online-en.html) offers access to **Xeloda** for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.