--- title: Buy Ethionamide 250mg Tuberculosis Pills description: Ethionamide 250mg pills treat tuberculosis as part of combination therapy. Order this antibiotic medication from our secure pharmacy. type: product language: en url: https://liabilis.com/order-ethionamide-online-en.html availability: in_stock shipping: - type: Standard Airmail price: 10.00 currency: USD area: Worldwide time: 14-21 days - type: Tracked Express price: 30.00 currency: USD area: Worldwide tracking: true time: 5-9 days price_min: 170.99 price_max: 737.19 currency: USD offers: - name: 250mg x 30 pills price: 170.99 - name: 250mg x 60 pills price: 320.14 - name: 250mg x 90 pills price: 471.99 - name: 250mg x 120 pills price: 543.39 - name: 250mg x 180 pills price: 737.19 --- # Buy Ethionamide 250mg Tuberculosis Pills Ethionamide is an antibiotic medication used in combination therapy to treat active tuberculosis, particularly drug-resistant strains. This medication works by inhibiting the growth of tuberculosis bacteria and is part of comprehensive TB treatment regimens. Our pharmacy offers reliable access to Ethionamide in 250mg pill form for patients requiring tuberculosis treatment under medical supervision. ## Pricing and Options | Dosage | Pack Size | Price (USD) | Price Per Pill | Status | | :--- | :--- | :--- | :--- | :--- | | **250mg** | 30 pills | **$170.99** | $5.70 | In Stock | | **250mg** | 60 pills | **$320.14** | $5.34 | In Stock | | **250mg** | 90 pills | **$471.99** | $5.24 | In Stock | | **250mg** | 120 pills | **$543.39** | $4.53 | In Stock | | **250mg** | 180 pills | **$737.19** | $4.09 | In Stock | [Buy Now](https://liabilis.com/order-ethionamide-online-en.html) ## Introduction Ethionamide is a synthetic anti-tuberculosis (TB) medication supplied as a 250 mg oral pill. It belongs to the thioamide class of antimycobacterial agents and is primarily used as a second-line drug for multidrug-resistant (MDR) or extensively drug-resistant (XDR) tuberculosis. The active ingredient is ethionamide itself, and the tablet formulation is the most common dosage form available worldwide. In addition to its main indication for resistant TB, ethionamide may be employed in certain complex TB regimens when first-line agents are ineffective or contraindicated. ## Quick Reference Facts **Active Ingredient** : Ethionamide **Form** : pill 250 mg **Primary Uses** : - MDR-TB treatment - XDR-TB treatment ## What is Ethionamide? Ethionamide is the generic version of medications that contain the active compound ethionamide. It is classified as a second-line antimycobacterial agent within the thioamide therapeutic class. The drug was first synthesized in the 195s and has been incorporated into global TB programs as a component of combination therapy for drug-resistant disease. In many markets it is marketed under brand names such as **Tebursol** and the former **Ethion**. Because it is a generic product, it is bioequivalent to those brand-named equivalents and typically offers a lower cost to patients while delivering the same therapeutic effect. ## How Ethionamide Works Ethionamide is a pro-drug that requires activation by the mycobacterial enzyme EthA, a flavin-containing monooxygenase. Once activated, ethionamide forms an adduct that inhibits the enzyme InhA, an enoyl-ACP reductase essential for the synthesis of mycolic acids-key components of the mycobacterial cell wall. By blocking mycolic acid production, the drug compromises cell wall integrity, leading to bacterial death. Onset of action is not immediate; therapeutic concentrations are typically achieved within a few days, but the full bactericidal effect may require several weeks of continued therapy. Ethionamide is metabolized mainly in the liver through oxidation and conjugation pathways and is excreted predominantly in the urine. Its half-life ranges from 2 to 6 hours, necessitating multiple daily doses to maintain effective plasma levels. ## Conditions Treated with Ethionamide - **Multidrug-Resistant Tuberculosis (MDR-TB)** MDR-TB is defined as TB that is resistant at least to isoniazid and rifampicin. Ethionamide provides an alternative mechanism of action, allowing clinicians to construct effective regimens when first-line drugs fail. - **Extensively Drug-Resistant Tuberculosis (XDR-TB)** XDR-TB adds resistance to fluoroquinolones and at least one second-line injectable. Ethionamide is often retained in the regimen because its resistance profile is usually independent of those agents. - **Complicated Pulmonary TB Requiring Individualized Therapy** In cases where adverse reactions or drug-drug interactions limit the use of other second-line drugs, ethionamide may replace a member of the regimen to preserve overall efficacy. ## Is Ethionamide the Right Medication for You? Ethionamide is appropriate for adults diagnosed with MDR-TB or XDR-TB who need an additional oral agent with a distinct target. It is most beneficial when combined with other effective drugs, such as fluoroquinolones, linezolid, or injectable agents, as part of a WHO-recommended regimen. Patients with normal liver function, no known hypersensitivity to thioamides, and the ability to tolerate a thrice-daily dosing schedule are typical candidates. Contraindications include severe hepatic impairment, known allergy to ethionamide, and pregnancy (the drug is classified as pregnancy category C; risks must be weighed against benefits). Elderly individuals and those with pre-existing peripheral neuropathy should be monitored closely, as they are at higher risk for toxicity. ## Buying Ethionamide from [our online pharmacy](https://liabilis.com/order-ethionamide-online-en.html) ### Why Choose Our Service? Accessing second-line TB medicines can be challenging through conventional pharmacies, especially when supply chains are limited or insurance coverage is restrictive. Our platform provides a reliable source for ethionamide, helping patients obtain the drug quickly and affordably. ### Quality & Safety Assurance We partner with licensed international pharmacies to ensure quality and authenticity. Every batch of ethionamide is sourced from manufacturers that comply with Good Manufacturing Practice (GMP) standards and is verified by third-party laboratories before shipment. ### Pricing & Access Because ethionamide is available as a generic, we can offer it at a price close to the manufacturer’s cost, often substantially lower than brand-named equivalents such as Tebursol. This cost advantage makes prolonged TB regimens more financially sustainable for patients and healthcare programs. ### Discreet Delivery Your privacy matters. Orders are packaged in unmarked, tamper-evident envelopes and shipped via express couriers that typically deliver within 7 days, or through standard airmail in approximately 3 weeks. Tracking information is provided for every shipment, ensuring you can monitor its progress securely. ## Use: Dosing, Missed Dose, Overdose - **Standard Dosing** Adults generally receive 15-20 mg/kg/day, divided into two or three doses of 250 mg tablets. Typical regimens range from 500 mg twice daily to 750 mg three times daily, adjusted according to body weight, hepatic function, and treatment response. - **Missed Dose** If you forget a dose and it is less than 6 hours until the next scheduled dose, take the missed tablet promptly. If it is closer to the next dose, skip the missed tablet and resume the regular dosing schedule; do not double-dose. - **Overdose** In the event of a suspected overdose, contact your local emergency department or poison control centre immediately. Symptoms may include severe nausea, vomiting, dizziness, or hepatic discomfort. Prompt medical evaluation and supportive care are essential. - **Administration Tips** Take ethionamide with food to reduce gastrointestinal irritation. Avoid alcohol, as it can increase liver stress. Refrain from operating heavy machinery until you know how the medication affects you, especially during the first few days. ## Safety Information ### ⚠️ Who Should Not Take Ethionamide - Documented hypersensitivity to ethionamide or any thioamide compounds. - Severe hepatic impairment (e.g., Child-Pugh class C). - Pregnancy, unless the prescribing clinician determines that the benefit outweighs potential fetal risk. ### Common Side Effects - **Gastrointestinal:** nausea, vomiting, abdominal pain, loss of appetite. - **Neurological:** peripheral neuropathy, dizziness, headache. - **Endocrine:** mild hypothyroidism; routine thyroid function testing is advised during prolonged therapy. These effects are generally dose-related and may improve with dose adjustment or symptomatic treatment (e.g., anti-emetics). ### Serious Side Effects (Seek Immediate Medical Help) - **Hepatotoxicity:** jaundice, dark urine, right-upper-quadrant pain. - **Severe peripheral neuropathy:** numbness or tingling that progresses rapidly. - **Optic neuritis or visual disturbances:** sudden loss of vision or color perception. If any of these occur, discontinue ethionamide and obtain urgent medical assessment. ### Drug & Food Interactions - **Thyroid hormone replacement (levothyroxine):** ethionamide may augment hypothyroid effects; monitor thyroid levels. - **Other hepatotoxic agents (e.g., isoniazid, pyrazinamide):** concurrent use increases liver injury risk; liver function tests should be performed frequently. - **Anticoagulants (warfarin):** ethionamide may potentiate anticoagulant effect; INR monitoring is recommended. - **Alcohol:** may exacerbate hepatic toxicity; avoidance is advised. ## Off-Label and Investigational Uses of Ethionamide - **Mycobacterium avium Complex (MAC) Infections** - Small case series have reported clinical improvement when ethionamide was added to multi-drug regimens for disseminated MAC, but robust trial data are lacking. - **Nontuberculous Mycobacterial Skin Infections** - Some dermatology reports describe successful topical or systemic ethionamide use for refractory cutaneous infections; evidence remains anecdotal. These applications are not approved by major regulatory agencies and should only be considered under specialist supervision with informed consent. ## Storage & Handling - Store tablets at 15 °C - 30 °C (59 °F - 86 °F) in a dry place, away from direct sunlight and moisture. - Keep the container tightly closed to protect from humidity. - Do not use tablets past the printed expiration date. - Dispose of unused medication according to local hazardous waste guidelines or return to a pharmacy for proper disposal. ## Frequently Asked Questions **Practical Use & Lifestyle** - **Can I travel internationally with ethionamide?** Yes, but carry a copy of the prescription and a physician’s letter stating the medical necessity. Some countries require documentation for importation of second-line TB drugs. - **Should I avoid certain foods while taking ethionamide?** There are no specific food restrictions, but taking the medication with meals reduces stomach upset. Grapefruit juice does not have a known interaction. - **How should I store ethionamide in a hot climate?** Keep the bottle in a sealed container placed in a cool, shaded area, such as an air-conditioned room or insulated bag, to avoid excessive heat. **Product & Formulation Details** - **What do Ethionamide tablets look like?** Generic 250 mg tablets are typically white, round, and may be scored to allow splitting, though splitting is not always recommended due to dose accuracy concerns. - **Are there any inactive ingredients I should be aware of?** Common excipients include microcrystalline cellulose, lactose monohydrate, and magnesium stearate. Patients with lactose intolerance should discuss alternatives with their provider. **Regulatory & Safety Nuances** - **Will Ethionamide show up on a standard drug test?** Ethionamide is not part of routine occupational drug-screening panels, but specialized toxicology testing could detect it if specifically requested. - **Is Ethionamide approved for pediatric use?** It is not formally approved for children under 12 years; pediatric dosing is based on limited clinical data and is reserved for specialist-managed cases of MDR-TB. - **Can I take Ethionamide while pregnant?** The drug is classified as pregnancy category C. It should only be used if the potential benefit justifies the potential risk to the fetus, and this decision must be made by a qualified clinician. **Scientific & Clinical Curiosity** - **What was the original purpose of developing ethionamide?** Ethionamide was synthesized in the 195s as a thioamide analogue of isoniazid, aiming to overcome resistance mechanisms that limited isoniazid efficacy. - **How does ethionamide compare to the related drug protionamide?** Both are thioamides activated by EthA, but protionamide has a longer half-life and a slightly different side-effect profile, often causing more central nervous system disturbances. ## Glossary **Thioamide** : A class of compounds containing a carbon-sulfur double bond (C=S) that interferes with bacterial cell-wall synthesis, exemplified by ethionamide. **InhA** : Mycolic acid enoyl-reductase, an enzyme essential for the production of mycolic acids in Mycobacterium tuberculosis; it is the primary target of ethionamide after activation. **MDR-TB** : Multidrug-resistant tuberculosis, defined as disease resistant to at least isoniazid and rifampicin, the two most potent first-line anti-TB drugs. **Hepatotoxicity** : Chemical-induced liver injury that can manifest as elevated liver enzymes, jaundice, or liver failure; a recognized risk with many anti-TB agents. ## Disclaimer The information provided about **Ethionamide** is for general knowledge only. It does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. [our online pharmacy](https://liabilis.com/order-ethionamide-online-en.html) offers access to **Ethionamide** for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.